Profiling Oxidative Stress Markers and Cardiovascular Complications in Chronic Kidney Disease Patients Supplemented with Vitamin E

Overview

Journal Arch Med Sci Atheroscler Dis

Date 2024 Nov 19

PMID 39559176

Authors

Leila Azouaou

Mounir Adnane

Omar Chabati

Medina Arab

Toualbi Chahine

Henni Chader

Affiliations

Soon will be listed here.

Abstract

Introduction: Cardiovascular diseases are common complications in chronic kidney disease (CKD). Oxidative stress associated with renal and metabolic dysfunctions is one of the cardiovascular complications (CVC) in haemodialysis patients. The aim of the present study is to analyse the oxidative stress markers in CDK patients supplemented with antioxidants and vitamin E, with monitoring of CVC.

Material And Methods: This was a cross-sectional study conducted on 99 subjects. CKD patients received oral supplementation of vitamin E (300 mg/day) for 2 years. Oxidative stress markers, nitric oxide (NO); myeloperoxidase (MPO); oxidized low-density lipoprotein (LDLox); malondialdehyde (MDA) and glutathione were measured before and after the vitamin treatment.

Results: NO (62.62 ±2.80 μmol/l), LDLox (10.55 ±4.62 μmol/l), MDA (6.11 ±2.83 μmol/l) and MPO (53.35 ±3.82 UI/ml) were overconcentrated, while glutathione (62.09 ±4.15 UI/ml) was less concentrated in CKD patients with cardiovascular complications, compared to those without cardiovascular complications (67.08 ±1.90 μmol/l, 31.18 ±5.25 μmol/l, 16 ±6.47 μmol/l, 57.00 ±7.24 UI/ml, 43.09 ±3.33 UI/ml, respectively). After 2 years of vitamin E treatment, the overall cardiovascular complications were not significantly decreased.

Conclusions: These results showed that oral complementation with vitamin E did not affect the occurrence of cardiovascular complications associated with CKD. These findings may pave the way for future innovative strategies for antioxidant supplementation in CKD patients.

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