Clinical Applications of Near-infrared Diffuse Correlation Spectroscopy and Tomography for Tissue Blood Flow Monitoring and Imaging

Overview

Journal Physiol Meas

Specialties Biomedical Engineering
Biophysics
Physiology

Date 2017 Feb 16

PMID 28199219

Citations 33

Authors

Yu Shang

Ting Li

Guoqiang Yu

Affiliations

Soon will be listed here.

Abstract

Objective: Blood flow is one such available observable promoting a wealth of physiological insight both individually and in combination with other metrics.

Approach: Near-infrared diffuse correlation spectroscopy (DCS) and, to a lesser extent, diffuse correlation tomography (DCT), have increasingly received interest over the past decade as noninvasive methods for tissue blood flow measurements and imaging. DCS/DCT offers several attractive features for tissue blood flow measurements/imaging such as noninvasiveness, portability, high temporal resolution, and relatively large penetration depth (up to several centimeters).

Main Results: This review first introduces the basic principle and instrumentation of DCS/DCT, followed by presenting clinical application examples of DCS/DCT for the diagnosis and therapeutic monitoring of diseases in a variety of organs/tissues including brain, skeletal muscle, and tumor.

Significance: Clinical study results demonstrate technical versatility of DCS/DCT in providing important information for disease diagnosis and intervention monitoring.

Citing Articles

A Comprehensive Study of Reactive Oxygen Species Explicit Dosimetry for Pleural Photodynamic Therapy.

Sun H, Ong Y, Kim M, Dimofte A, Singhal S, Cengel K Antioxidants (Basel). 2025; 13(12).

PMID: 39765767 PMC: 11672818. DOI: 10.3390/antiox13121436.

Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies.

Fernandez Esteberena P, Cortese L, Zanoletti M, Lo Presti G, Aranda Velazquez G, Ruiz Janer S Biomed Opt Express. 2024; 15(12):7035-7055.

PMID: 39679411 PMC: 11640565. DOI: 10.1364/BOE.538141.

Diffuse correlation tomography: a technique to characterize tissue blood flow abnormalities in benign and malignant breast lesions.

Zhang R, Lu J, Di W, Gui Z, Chan S, Yang F Biomed Opt Express. 2024; 15(11):6259-6276.

PMID: 39553863 PMC: 11563337. DOI: 10.1364/BOE.535330.

Acoustomotive diffuse correlation spectroscopy for sensing mechanical stiffness in tissue-mimicking phantoms.

Di W, Zhang R, Gui Z, Shang Y Biomed Opt Express. 2024; 15(9):5328-5348.

PMID: 39296393 PMC: 11407260. DOI: 10.1364/BOE.531963.

Assessment of Microvascular Hemodynamic Adaptations in Finger Flexors of Climbers.

Ferrer-Uris B, Busquets A, Beslija F, Durduran T Bioengineering (Basel). 2024; 11(4).

PMID: 38671822 PMC: 11048441. DOI: 10.3390/bioengineering11040401.

References

Dietsche G, NINCK M, Ortolf C, Li J, Jaillon F, Gisler T . Fiber-based multispeckle detection for time-resolved diffusing-wave spectroscopy: characterization and application to blood flow detection in deep tissue. Appl Opt. 2007; 46(35):8506-14. DOI: 10.1364/ao.46.008506. View

Jaillon F, Li J, Dietsche G, Elbert T, Gisler T . Activity of the human visual cortex measured non-invasively by diffusing-wave spectroscopy. Opt Express. 2009; 15(11):6643-50. DOI: 10.1364/oe.15.006643. View

Henry B, Zhao M, Shang Y, Uhl T, Thomas D, Xenos E . Hybrid diffuse optical techniques for continuous hemodynamic measurement in gastrocnemius during plantar flexion exercise. J Biomed Opt. 2016; 20(12):125006. PMC: 4688865. DOI: 10.1117/1.JBO.20.12.125006. View

Zhou C, Choe R, Shah N, Durduran T, Yu G, Durkin A . Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy. J Biomed Opt. 2007; 12(5):051903. DOI: 10.1117/1.2798595. View

Baker W, Parthasarathy A, Ko T, Busch D, Abramson K, Tzeng S . Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts. Neurophotonics. 2015; 2(3):035004. PMC: 4524732. DOI: 10.1117/1.NPh.2.3.035004. View

Huang C, Radabaugh J, Aouad R, Lin Y, Gal T, Patel A . Noncontact diffuse optical assessment of blood flow changes in head and neck free tissue transfer flaps. J Biomed Opt. 2015; 20(7):075008. PMC: 4696658. DOI: 10.1117/1.JBO.20.7.075008. View

Cheung C, Culver J, Takahashi K, Greenberg J, Yodh A . In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies. Phys Med Biol. 2001; 46(8):2053-65. DOI: 10.1088/0031-9155/46/8/302. View

Busch D, Rusin C, Miller-Hance W, Kibler K, Baker W, Heinle J . Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest. Biomed Opt Express. 2016; 7(9):3461-3470. PMC: 5030024. DOI: 10.1364/BOE.7.003461. View

Durduran T, Zhou C, Buckley E, Kim M, Yu G, Choe R . Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects. J Biomed Opt. 2010; 15(3):037004. PMC: 2887915. DOI: 10.1117/1.3425884. View

10.

Franceschini M, Joseph D, Huppert T, Diamond S, Boas D . Diffuse optical imaging of the whole head. J Biomed Opt. 2006; 11(5):054007. PMC: 2637816. DOI: 10.1117/1.2363365. View

11.

Al-Rawi P, Kirkpatrick P . Tissue oxygen index: thresholds for cerebral ischemia using near-infrared spectroscopy. Stroke. 2006; 37(11):2720-5. DOI: 10.1161/01.STR.0000244807.99073.ae. View

12.

Boas D, Sakadzic S, Selb J, Farzam P, Franceschini M, Carp S . Establishing the diffuse correlation spectroscopy signal relationship with blood flow. Neurophotonics. 2016; 3(3):031412. PMC: 4904065. DOI: 10.1117/1.NPh.3.3.031412. View

13.

Busch D, Lynch J, Winters M, McCarthy A, Newland J, Ko T . Cerebral Blood Flow Response to Hypercapnia in Children with Obstructive Sleep Apnea Syndrome. Sleep. 2015; 39(1):209-16. PMC: 4678358. DOI: 10.5665/sleep.5350. View

14.

Baker W, Parthasarathy A, Busch D, Mesquita R, Greenberg J, Yodh A . Modified Beer-Lambert law for blood flow. Biomed Opt Express. 2014; 5(11):4053-75. PMC: 4242038. DOI: 10.1364/BOE.5.004053. View

15.

Huang C, Irwin D, Lin Y, Shang Y, He L, Kong W . Speckle contrast diffuse correlation tomography of complex turbid medium flow. Med Phys. 2015; 42(7):4000-6. PMC: 4464064. DOI: 10.1118/1.4922206. View

16.

Quaresima V, Ferrari M, Franceschini M, Hoimes M, Fantini S . Spatial distribution of vastus lateralis blood flow and oxyhemoglobin saturation measured at the end of isometric quadriceps contraction by multichannel near-infrared spectroscopy. J Biomed Opt. 2004; 9(2):413-20. DOI: 10.1117/1.1646417. View

17.

Zhou C, Yu G, Furuya D, Greenberg J, Yodh A, Durduran T . Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain. Opt Express. 2009; 14(3):1125-44. DOI: 10.1364/oe.14.001125. View

18.

Pine , WEITZ , Chaikin , Herbolzheimer . Diffusing wave spectroscopy. Phys Rev Lett. 1988; 60(12):1134-1137. DOI: 10.1103/PhysRevLett.60.1134. View

19.

Huang C, Seong M, Morgan J, Mazdeyasna S, Kim J, Hastings J . Low-cost compact diffuse speckle contrast flowmeter using small laser diode and bare charge-coupled-device. J Biomed Opt. 2016; 21(8):80501. PMC: 4975738. DOI: 10.1117/1.JBO.21.8.080501. View

20.

Favilla C, Mesquita R, Mullen M, Durduran T, Lu X, Kim M . Optical bedside monitoring of cerebral blood flow in acute ischemic stroke patients during head-of-bed manipulation. Stroke. 2014; 45(5):1269-74. PMC: 4006296. DOI: 10.1161/STROKEAHA.113.004116. View