Comparison of Cerebral Metabolic Rate of Oxygen, Blood Flow, and Bispectral Index Under General Anesthesia

Overview

Journal Neurophotonics

Date 2023 Mar 13

PMID 36911206

Authors

Susanna Tagliabue

Claus Lindner

Ivette Chochron da Prat

Angela Sanchez-Guerrero

Isabel Serra

Michal Kacprzak

Federica Maruccia

Olga Martinez Silva

Udo M Weigel

Miriam de Nadal

Maria A Poca

Turgut Durduran

Affiliations

Soon will be listed here.

Abstract

Significance: The optical measurement of cerebral oxygen metabolism was evaluated.

Aim: Compare optically derived cerebral signals to the electroencephalographic bispectral index (BIS) sensors to monitor propofol-induced anesthesia during surgery.

Approach: Relative cerebral metabolic rate of oxygen ( ) and blood flow (rCBF) were measured by time-resolved and diffuse correlation spectroscopies. Changes were tested against the relative BIS (rBIS) ones. The synchronism in the changes was also assessed by the R-Pearson correlation.

Results: In 23 measurements, optically derived signals showed significant changes in agreement with rBIS: during propofol induction, rBIS decreased by 67% [interquartile ranges (IQR) 62% to 71%], by 33% (IQR 18% to 46%), and rCBF by 28% (IQR 10% to 37%). During recovery, a significant increase was observed for rBIS (48%, IQR 38% to 55%), (29%, IQR 17% to 39%), and rCBF (30%, IQR 10% to 44%). The significance and direction of the changes subject-by-subject were tested: the coupling between the rBIS, , and rCBF was witnessed in the majority of the cases (14/18 and 12/18 for rCBF and 19/21 and 13/18 for in the initial and final part, respectively). These changes were also correlated in time ( to , ).

Conclusions: Optics can reliably monitor in such conditions.

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