HIV Cause-specific Deaths, Mortality, Risk Factors, and the Combined Influence of HAART and Late Diagnosis in Zhejiang, China, 2006-2013

Overview

Journal Sci Rep

Specialty Science

Date 2017 Feb 16

PMID 28198390

Citations 25

Authors

Lin Chen

Xiaohong Pan

Qiaoqin Ma

Jiezhe Yang

Yun Xu

Jinlei Zheng

Hui Wang

Xin Zhou

Tingting Jiang

Jun Jiang

Lin He

Jianmin Jiang

Affiliations

Soon will be listed here.

Abstract

To examine patterns of human immunodeficiency virus (HIV) cause-specific deaths, risk factors, and the effect of interactions on mortality, we conducted a retrospective cohort study in Zhejiang, China, from 2006 to 2013. All data were downloaded from the acquired immune deficiency syndrome (AIDS) Prevention and Control Information System. The Cox proportional hazards model was used to assess predictors of cause-specific death. The relative excess risk due to interaction and ratio of hazard ratios (RHR) were calculated for correlations between HAART, late diagnosis, and age. A total of 13,812 HIV/AIDS patients were enrolled with 31,553 person-years (PY) of follow-up. The leading causes of death of HIV patients were accidental death and suicide (21.5%), and the leading cause of death for those with AIDS was AIDS-defining disease (76.4%). Both additive and multiplicative scale correlations were found between receiving HAART and late diagnosis, with RERI of 5.624 (95% CI: 1.766-9.482) and RHR of 2.024 (95% CI: 1.167-2.882). The effects of HAART on AIDS-related mortalities were affected by late diagnosis. Early detection of HIV infection and increased uptake of HAART are important for greater benefits in terms of lives saved.

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