HIV and Aging: Emerging Research Issues

Overview

Journal Curr Opin HIV AIDS

Specialty Infectious Diseases

Date 2014 May 15

PMID 24824891

Citations 29

Authors

Peter W Hunt

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: It is now widely accepted that HIV-infected individuals remain at a higher risk for mortality and age-related morbidities than the general population, but several unresolved issues need to be addressed by the research community in the coming years to further improve the health of HIV-infected individuals in the modern treatment era.

Recent Findings: Although recent studies have helped to better define the contribution of HIV to life expectancy and morbidity in the modern antiretroviral therapy (ART) era, questions remain about the generalizability of these findings to a future HIV-infected population that is expected to be much older. Furthermore, although a consensus has emerged that the persistent inflammatory state contributes to morbidity and mortality in this setting, the relative contributions of this process, health-related behaviours, comorbidities and medication toxicities remain incompletely understood. Lastly, significant uncertainty remains over the root causes of the persistent inflammatory state, the specific immunologic pathways to target with interventions and the most appropriate biomarkers to use for surrogate outcomes in pilot trials of immune-based interventions.

Summary: Each of these issues will be addressed in this review, highlighting recently published and presented studies that inform the discussion, and recommendations will be made for prioritizing the future research agenda.

Citing Articles

Healthcare resource utilization and costs associated with renal, bone and cardiovascular comorbidities among persons living with HIV compared to the general population in Quebec, Canada.

Baribeau V, Kim C, Lorgeoux R, Brisebois J, Tossonian H, Lachaine J PLoS One. 2022; 17(7):e0262645.

PMID: 35816474 PMC: 9273062. DOI: 10.1371/journal.pone.0262645.

Association between HIV and Prevalent Hypertension and Diabetes Mellitus in South Africa: Analysis of a Nationally Representative Cross-Sectional Survey.

Magodoro I, Okello S, Dungeni M, Castle A, Mureyani S, Danaei G Int J Infect Dis. 2022; 121:217-225.

PMID: 35597557 PMC: 9337715. DOI: 10.1016/j.ijid.2022.05.035.

A Systematic Review of Risk Factors for Suicide Among Persons Living with HIV (1996-2020).

Smith A, Breazeale S, Goulet J, Vlahov D, Justice A, Womack J AIDS Behav. 2022; 26(8):2559-2573.

PMID: 35107660 DOI: 10.1007/s10461-022-03591-y.

Expression of Killer Immunoglobulin Receptor Genes among HIV-Infected Individuals with Non-AIDS Comorbidities.

Abou Hassan F, Bou Hamdan M, El Asmar K, Melhem N J Immunol Res. 2022; 2022:1119611.

PMID: 35071606 PMC: 8769865. DOI: 10.1155/2022/1119611.

Identification of Youthful Neurocognitive Trajectories in Adults Aging with HIV: A Latent Growth Mixture Model.

Saloner R, Lobo J, Paolillo E, Campbell L, Letendre S, Cherner M AIDS Behav. 2021; 26(6):1966-1979.

PMID: 34878634 PMC: 9046348. DOI: 10.1007/s10461-021-03546-9.

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