A Comparative Analysis on Characteristics and Mortalities of Four Key Transmission Populations on Antiretroviral Therapy: a Retrospective Cohort Study in Northwest China

Overview

Journal BMC Infect Dis

Publisher Biomed Central

Specialty Infectious Diseases

Date 2022 Mar 29

PMID 35346084

Authors

Shuo Feng

Zirong Zhu

Pengju Yang

Juan Jin

Huihui Tuo

Ning Wang

Ruimin Bai

Yan Sun

Liumei Song

Xiu Zhang

Shengbang Wang

Qiqi Duan

Yingjian Huang

Yan Zheng

Songhua Xu

Affiliations

Soon will be listed here.

Abstract

Background: This study explored disparities in characteristics and mortalities among four major transmission groups on antiretroviral therapy in northwest China as well as the survival impact of each transmission route.

Methods: We first examined disparities in demographics and clinical characteristics of the four transmission populations. Kaplan Meier analysis was subsequently conducted to compare survival rates among all groups. At last, Cox proportional hazards regression model was employed to analyze the survival impact of a transmission route among seven main categories of survival factors associated with all-cause mortalities.

Results: Survival analysis showed significant differences in all-cause, AIDS- and non-AIDS-related deaths among four HIV populations (all P < 0.05). Using homosexuals as the reference, Cox proportional hazards model further revealed that the risk of all-cause death for blood and plasma donors was significantly higher than that of the reference (aHR: 5.21, 95%CI: 1.54-17.67); the risk of non-AIDS-related death for heterosexuals (aHR: 2.07, 95%CI: 1.01-4.20) and that for blood and plasma donors (aHR: 19.81, 95%CI: 5.62-69.89) were both significantly higher than that of the reference.

Conclusions: Significant disparities were found in characteristics and mortalities among the four transmission groups where mortality disparities were mainly due to non-AIDS-related death. Suggestions are provided for each group to improve their survivorship.

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