Serum 25-hydroxyvitamin D and Bone Turnover Markers in Palestinian Postmenopausal Osteoporosis and Normal Women

Overview

Journal Arch Osteoporos

Publisher Springer

Date 2017 Jan 27

PMID 28124221

Citations 15

Authors

Akram Kharroubi

Elias Saba

Riham Smoom

Khaldoun Bader

Hisham Darwish

Affiliations

Soon will be listed here.

Abstract

Purpose: The purpose of this study was to investigate the association of bone mineral density (BMD) with serum vitamin D levels, parathyroid hormone (PTH), calcium, obesity, and bone turnover markers in Palestinian postmenopausal women.

Methods: Three hundred eighty-two postmenopausal women (≥45 years) were recruited from various women clinics for BMD assessment (131 women had osteoporosis and 251 were normal and served as controls). Blood samples were obtained for serum calcium, PTH, 25(OH)D, bone formation (N-terminal propeptide (PINP)), and bone resorption (serum C-terminal telopeptide of type I collagen (CTX1)) markers.

Results: Women with osteoporosis had statistically significant lower mean weight, height, body mass index (BMI), and serum calcium (p < 0.05) compared to controls. No significant differences were detected between the mean values of bone turnover markers (CTX and PINP), 25(OH)D, and PTH of the two groups. Women with vitamin D deficiency (severe and insufficiency) represented 85.9% of the study subjects. Multiple and logistic regression showed that age and BMI significantly affected BMD and vitamin D had a significant association with BMD only at the lumbar spine. BMI was positively correlated with BMD and PTH but negatively correlated with vitamin D. Logistic regression showed that the odds ratio (OR) for having osteoporosis decreased with increasing BMI (overweight OR = 0.11, p = 0.053; obese OR = 0.05, p = 0.007).

Conclusions: There was no direct correlation between BMD and PTH, bone turnover markers, and vitamin D except at the lumbar spine. A negative correlation between BMD and age and a positive correlation with BMI were observed. The protective effect of obesity on osteoporosis was complicated by the effect of obesity on vitamin D and PTH.

Citing Articles

Assessment of the vitamin D status and its determinants in young healthy students from Palestine.

Lenz J, Tintle N, Kerlikowsky F, Badrasawi M, Zahdeh R, Qasrawi R J Nutr Sci. 2024; 12:e38.

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Vitamin D status and its associations with bone mineral density, bone turnover markers, and parathyroid hormone in Chinese postmenopausal women with osteopenia and osteoporosis.

Chen X, Shen L, Gao C, Weng R, Fan Y, Xu S Front Nutr. 2024; 10:1307896.

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Mobasseri M, Tarverdizadeh N, Mirghafourvand M, Salehi-Pourmehr H, Ostadrahimi A, Farshbaf-Khalili A J Res Med Sci. 2023; 28:54.

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Du Y, Xie B, Wang M, Zhong Y, Lv Z, Luo Y Front Endocrinol (Lausanne). 2023; 14:1159241.

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Dadda S, El Houate B, El Bouhali B Arch Osteoporos. 2022; 18(1):14.

PMID: 36574180 DOI: 10.1007/s11657-022-01204-8.

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