Serum 25-OH Vitamin D in Relation to Bone Mineral Density and Bone Turnover

Overview

Journal Int J Endocrinol

Publisher Wiley

Specialty Endocrinology

Date 2014 Aug 12

PMID 25110474

Citations 18

Authors

Nicola Napoli

Rocky Strollo

Delia Sprini

Ernesto Maddaloni

Giovam Battista Rini

Enrico Carmina

Affiliations

Soon will be listed here.

Abstract

It is unclear which vitamin D status is optimal for bone health. In this study, we aimed to assess cutoffs of 25-hydroxyvitamin D (25OHD) derived by the literature (20, 25, or 30 ng/mL) in relation to bone turnover and bone mineral density (BMD). Serum 25OHD, PTH, osteocalcin, bone alkaline phosphatase, and C-telopeptide were measured in 274 consecutive postmenopausal women. BMD of the lumbar spine (L1-L4) and of femoral neck were also evaluated. 50 patients had normal BMD, while 124 had osteopenia and 100 had osteoporosis. 37.6%, 56.2%, and 70.8% subjects had serum 25OHD lower than 20, 25, or 30 ng/mL, respectively. No differences in bone turnover markers were found when comparing patients with low 25OHD defined according to the different cutoffs. However, a cutoff of 25 ng/mL appeared to differentiate better than a cutoff of 30 ng/mL in those subjects with reduced femoral neck BMD. The PTH plateau occurred at 25OHD levels of 26-30 ng/mL. In conclusion, vitamin D deficiency is common in Sicilian postmenopausal women and it may be associated with low BMD and increased bone turnover markers. Further studies are needed to better define the right cutoff for normal vitamin D levels in postmenopausal women.

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References

Isaia G, Giorgino R, Rini G, Bevilacqua M, Maugeri D, Adami S . Prevalence of hypovitaminosis D in elderly women in Italy: clinical consequences and risk factors. Osteoporos Int. 2003; 14(7):577-82. DOI: 10.1007/s00198-003-1390-7. View

Morris H, MORRISON G, Burr M, Thomas D, Nordin B . Vitamin D and femoral neck fractures in elderly South Australian women. Med J Aust. 1984; 140(9):519-21. DOI: 10.5694/j.1326-5377.1984.tb108222.x. View

Cauley J, LaCroix A, Wu L, Horwitz M, Danielson M, Bauer D . Serum 25-hydroxyvitamin D concentrations and risk for hip fractures. Ann Intern Med. 2008; 149(4):242-50. PMC: 2743412. DOI: 10.7326/0003-4819-149-4-200808190-00005. View

Gloth 3rd F, Gundberg C, Hollis B, Haddad Jr J, Tobin J . Vitamin D deficiency in homebound elderly persons. JAMA. 1995; 274(21):1683-6. DOI: 10.1001/jama.1995.03530210037027. View

Fradinger E, Zanchetta J . Vitamin D and bone mineral density in ambulatory women living in Buenos Aires, Argentina. Osteoporos Int. 2001; 12(1):24-7. DOI: 10.1007/s001980170153. View

Baker M, McDONNELL H, Peacock M, Nordin B . Plasma 25-hydroxy vitamin D concentrations in patients with fractures of the femoral neck. Br Med J. 1979; 1(6163):589. PMC: 1598358. DOI: 10.1136/bmj.1.6163.589. View

Holick M, Siris E, Binkley N, Beard M, Khan A, Katzer J . Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy. J Clin Endocrinol Metab. 2005; 90(6):3215-24. DOI: 10.1210/jc.2004-2364. View

Heaney R, Holick M . Why the IOM recommendations for vitamin D are deficient. J Bone Miner Res. 2011; 26(3):455-7. DOI: 10.1002/jbmr.328. View

Collins D, JASANI C, Fogelman I, Swaminathan R . Vitamin D and bone mineral density. Osteoporos Int. 1998; 8(2):110-4. DOI: 10.1007/BF02672505. View

10.

Brot C, Vestergaard P, Kolthoff N, Gram J, Hermann A, Sorensen O . Vitamin D status and its adequacy in healthy Danish perimenopausal women: relationships to dietary intake, sun exposure and serum parathyroid hormone. Br J Nutr. 2001; 86 Suppl 1:S97-103. DOI: 10.1079/bjn2001345. View

11.

Lips P, Duong T, Oleksik A, Black D, Cummings S, Cox D . A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. J Clin Endocrinol Metab. 2001; 86(3):1212-21. DOI: 10.1210/jcem.86.3.7327. View

12.

Islam M, Lamberg-Allardt C, Karkkainen M, Outila T, Salamatullah Q, Shamim A . Vitamin D deficiency: a concern in premenopausal Bangladeshi women of two socio-economic groups in rural and urban region. Eur J Clin Nutr. 2002; 56(1):51-6. DOI: 10.1038/sj.ejcn.1601284. View

13.

Sato Y, Asoh T, Kondo I, Satoh K . Vitamin D deficiency and risk of hip fractures among disabled elderly stroke patients. Stroke. 2001; 32(7):1673-7. DOI: 10.1161/01.str.32.7.1673. View

14.

Villareal D, Civitelli R, Chines A, Avioli L . Subclinical vitamin D deficiency in postmenopausal women with low vertebral bone mass. J Clin Endocrinol Metab. 1991; 72(3):628-34. DOI: 10.1210/jcem-72-3-628. View

15.

Looker A, Mussolino M . Serum 25-hydroxyvitamin D and hip fracture risk in older U.S. white adults. J Bone Miner Res. 2007; 23(1):143-50. DOI: 10.1359/jbmr.071003. View

16.

Mezquita-Raya P, Munoz-Torres M, Luna J, Luna V, Lopez-Rodriguez F, Escobar-Jimenez F . Relation between vitamin D insufficiency, bone density, and bone metabolism in healthy postmenopausal women. J Bone Miner Res. 2001; 16(8):1408-15. DOI: 10.1359/jbmr.2001.16.8.1408. View

17.

Napoli N, Strollo R, Paladini A, Briganti S, Pozzilli P, Epstein S . The alliance of mesenchymal stem cells, bone, and diabetes. Int J Endocrinol. 2014; 2014:690783. PMC: 4124651. DOI: 10.1155/2014/690783. View

18.

Adami S, Bertoldo F, Braga V, Fracassi E, Gatti D, Gandolini G . 25-hydroxy vitamin D levels in healthy premenopausal women: association with bone turnover markers and bone mineral density. Bone. 2009; 45(3):423-6. DOI: 10.1016/j.bone.2009.05.012. View

19.

Bischoff-Ferrari H, Dietrich T, Orav E, Dawson-Hughes B . Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med. 2004; 116(9):634-9. DOI: 10.1016/j.amjmed.2003.12.029. View

20.

Hordon L, Peacock M . Vitamin D metabolism in women with femoral neck fracture. Bone Miner. 1987; 2(5):413-26. View