Prevalence of Vitamin D Deficiency Among Hemodialysis Patients in Palestine: A Cross-Sectional Study

Overview

Journal Int J Nephrol

Publisher Wiley

Specialty Nephrology

Date 2021 Apr 1

PMID 33791129

Citations 2

Authors

Zaher A Nazzal

Zakaria Hamdan

Nihal Natour

Maram Barbar

Rawan Rimawi

Eziyeh Salaymeh

Affiliations

Soon will be listed here.

Abstract

Introduction: The level of vitamin D status and its relationship to kidney function and liver function among patients with and without type 2 diabetes were not studied among Palestinian hemodialysis patients before. The aim of this study was to assess the status of vitamin D in hemodialysis patients with and without type 2 diabetes and its determinants.

Methods: Data were collected on 163 patients on hemodialysis therapy in the Nephrology Department at Najah National University Hospital. Information on age, sex, plasma 25 (OH)D, serum calcium, serum phosphate, parathyroid hormone, dialysis period, hypertension, diabetes, ALT, AST, albumin, alkaline phosphates, and BMI was obtained from the medical records. Data were analyzed using SPSS. . The mean level of 25 (OH)D was 17.3 ± 10.5 ng/ml. Only 12.9% of subjects had 25 (OH)D levels >30 ng/ml, whereas 65% had levels between 10 and 30 ng/ml; the remaining 22.1% were severely vitamin D deficient (<10 ng/ml). Vitamin D deficiency was more prevalent among females. It was not related to PTH, calcium, kidney, or liver function tests.

Conclusion: Vitamin D deficiency is highly prevalent among patients on hemodialysis with or without DM2.

Citing Articles

Assessment of Vitamin D Metabolism Disorders in Hemodialysis Patients.

Hryciuk M, Heleniak Z, Malgorzewicz S, Kowalski K, Antosiewicz J, Koelmer A Nutrients. 2025; 17(5).

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Assessment of the vitamin D status and its determinants in young healthy students from Palestine.

Lenz J, Tintle N, Kerlikowsky F, Badrasawi M, Zahdeh R, Qasrawi R J Nutr Sci. 2024; 12:e38.

PMID: 38415242 PMC: 10897509. DOI: 10.1017/jns.2023.25.

Vitamin D level, pain severity and quality of life among hemodialysis patients: a cross-sectional study.

Ishtawi S, Jomaa D, Nizar A, Abdalla M, Hamdan Z, Nazzal Z Sci Rep. 2023; 13(1):1182.

PMID: 36681707 PMC: 9867695. DOI: 10.1038/s41598-022-25793-z.

References

de Boer I, Ioannou G, Kestenbaum B, Brunzell J, Weiss N . 25-Hydroxyvitamin D levels and albuminuria in the Third National Health and Nutrition Examination Survey (NHANES III). Am J Kidney Dis. 2007; 50(1):69-77. DOI: 10.1053/j.ajkd.2007.04.015. View

Zhang T, Ju H, Chen H, Wen W . Comparison of Paricalcitol and Calcitriol in Dialysis Patients With Secondary Hyperparathyroidism: A Meta-Analysis of Randomized Controlled Studies. Ther Apher Dial. 2018; 23(1):73-79. DOI: 10.1111/1744-9987.12760. View

Feng X, Wen Y, Peng F, Wang N, Zhan X, Wu X . Association between aminotransferase/alanine aminotransferase ratio and cardiovascular disease mortality in patients on peritoneal dialysis: a multi-center retrospective study. BMC Nephrol. 2020; 21(1):209. PMC: 7268679. DOI: 10.1186/s12882-020-01840-7. View

Grzegorzewska A, Izdebska A, Niepolski L, Warchol W, Jagodzinski P . Self-Reported Physical Activity, Quality of Life, and Psychological Status in Relation to Plasma 25-Hydroxyvitamin D Concentration in Patients Treated with Hemodialysis. Kidney Blood Press Res. 2016; 41(6):886-900. DOI: 10.1159/000452585. View

Yeter H, Korucu B, Bali E, Derici U . Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis. Int J Vitam Nutr Res. 2020; 91(3-4):335-342. DOI: 10.1024/0300-9831/a000641. View

Elsheikh N, Sherif N, Zeid S, Eldamarawy M, Ali A, Sabry A . The link between bone disease and cardiovascular complications in hemodialysis patients. Electron Physician. 2016; 8(6):2483-8. PMC: 4965197. DOI: 10.19082/2483. View

Hou Y, Lu C, Lu K . Mineral bone disorders in chronic kidney disease. Nephrology (Carlton). 2018; 23 Suppl 4:88-94. DOI: 10.1111/nep.13457. View

Kharroubi A, Saba E, Smoom R, Bader K, Darwish H . Serum 25-hydroxyvitamin D and bone turnover markers in Palestinian postmenopausal osteoporosis and normal women. Arch Osteoporos. 2017; 12(1):13. PMC: 5266783. DOI: 10.1007/s11657-017-0306-7. View

Namir Y, Cohen M, Haviv Y, Slotki I, Shavit L . Vitamin D levels, vitamin D supplementation, and prognosis in patients with chronic kidney disease . Clin Nephrol. 2016; 86(10):165-74. DOI: 10.5414/CN108796. View

10.

Khader M, Snouber S, Alkhatib A, Nazzal Z, Dudin A . Prevalence of patients with end-stage renal disease on dialysis in the West Bank, Palestine. Saudi J Kidney Dis Transpl. 2013; 24(4):832-7. DOI: 10.4103/1319-2442.113913. View

11.

Pittas A, Dawson-Hughes B, Li T, van Dam R, Willett W, Manson J . Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care. 2006; 29(3):650-6. DOI: 10.2337/diacare.29.03.06.dc05-1961. View

12.

Kazama J, Wakasugi M . Parathyroid Hormone and Bone in Dialysis Patients. Ther Apher Dial. 2018; 22(3):229-235. DOI: 10.1111/1744-9987.12678. View

13.

Norman A . From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr. 2008; 88(2):491S-499S. DOI: 10.1093/ajcn/88.2.491S. View

14.

van Driel M, Koedam M, Buurman C, Hewison M, Chiba H, Uitterlinden A . Evidence for auto/paracrine actions of vitamin D in bone: 1alpha-hydroxylase expression and activity in human bone cells. FASEB J. 2006; 20(13):2417-9. DOI: 10.1096/fj.06-6374fje. View

15.

Forman J, Giovannucci E, Holmes M, Bischoff-Ferrari H, Tworoger S, Willett W . Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension. 2007; 49(5):1063-9. DOI: 10.1161/HYPERTENSIONAHA.107.087288. View

16.

Shahwan M, Ait Gacem S, Zaidi S . Prevalence of Diabetic Nephropathy and associated risk factors among type 2 diabetes mellitus patients in Ramallah, Palestine. Diabetes Metab Syndr. 2019; 13(2):1491-1496. DOI: 10.1016/j.dsx.2019.02.017. View

17.

Chen Z, Zhang X, Han F, Xie X, Hua Z, Huang X . High alkaline phosphatase and low intact parathyroid hormone associate with worse clinical outcome in peritoneal dialysis patients. Perit Dial Int. 2020; 41(2):236-243. DOI: 10.1177/0896860820918131. View

18.

Lu R, Zhu S, Tang F, Zhu X, Fan Z, Wang G . Effects of vitamin D or its analogues on the mortality of patients with chronic kidney disease: an updated systematic review and meta-analysis. Eur J Clin Nutr. 2017; 71(6):683-693. DOI: 10.1038/ejcn.2017.59. View

19.

Gracia-Iguacel C, Gallar P, Qureshi A, Ortega O, Mon C, Ortiz M . Vitamin D deficiency in dialysis patients: effect of dialysis modality and implications on outcome. J Ren Nutr. 2010; 20(6):359-67. DOI: 10.1053/j.jrn.2010.03.005. View

20.

Zheng Z, Shi H, Jia J, Li D, Lin S . Vitamin D supplementation and mortality risk in chronic kidney disease: a meta-analysis of 20 observational studies. BMC Nephrol. 2013; 14:199. PMC: 3851063. DOI: 10.1186/1471-2369-14-199. View