MiR-506 Suppresses Neuroblastoma Metastasis by Targeting ROCK1

Overview

Journal Oncol Lett

Specialty Oncology

Date 2017 Jan 27

PMID 28123576

Citations 12

Authors

Dianguo Li

Yanhua Cao

Jinliang Li

Jialong Xu

Qian Liu

Xiaogang Sun

Affiliations

Soon will be listed here.

Abstract

Neuroblastoma is a complex form of cancer with highly heterogeneous clinical behavior that arises during childhood from precursor cells of the sympathetic nervous system. In patients with neuroblastoma, mortality often occurs as a result of metastasis. The disease predominantly spreads to bone marrow, with a survival rate of ~40%. The current study demonstrates that microRNA (miR)-506 directly targets and downregulates Rho-associated, coiled-coil containing protein kinase 1 (ROCK1) in transforming growth factor (TGF)-β non-canonical pathways. It may be concluded that ROCK1 contributes to the invasion and migration of neuroblastoma cells by directly downregulating miR-506; thus, leading to the upregulation of ROCK1, which promotes cell invasion and migration. The present results provide a novel understanding of how miR-506 directly regulates TGF-β non-canonical signaling.

Citing Articles

Implication of non-coding RNA-mediated ROCK1 regulation in various diseases.

Ghafouri-Fard S, Poornajaf Y, Hussen B, Abak A, Shoorei H, Taheri M Front Mol Biosci. 2022; 9:986722.

PMID: 36177350 PMC: 9513225. DOI: 10.3389/fmolb.2022.986722.

circSYPL1 Promotes the Proliferation and Metastasis of Hepatocellular Carcinoma via the Upregulation of EZH2 Expression by Competing with hsa-miR-506-3p.

Lei D, Wang T J Oncol. 2022; 2022:2659563.

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Long non-coding RNA FOXD2-AS1 promotes cell proliferation, metastasis and EMT in glioma by sponging miR-506-5p.

Zhao J, Zeng X, Zhang H, Xiang J, Liu Y Open Med (Wars). 2020; 15(1):921-931.

PMID: 33336050 PMC: 7711959. DOI: 10.1515/med-2020-0175.

LncRNA DLX6-AS1 Promotes the Progression of Neuroblastoma by Activating STAT2 via Targeting miR-506-3p.

Hu Y, Sun H, Hu J, Zhang X Cancer Manag Res. 2020; 12:7451-7463.

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Long noncoding RNA LINC01410 promotes the tumorigenesis of neuroblastoma cells by sponging microRNA-506-3p and modulating WEE1.

Mi J, Han Y, Zhang J, Hao X, Xing M, Shang C Cancer Med. 2020; 9(21):8133-8143.

PMID: 32886453 PMC: 7643657. DOI: 10.1002/cam4.3398.

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