The Roles of MicroRNAs in Neuroblastoma

Overview

Journal World J Pediatr

Specialty Pediatrics

Date 2014 Jan 28

PMID 24464658

Citations 22

Authors

Hong Mei

Zhen-Yu Lin

Qiang-Song Tong

Affiliations

Soon will be listed here.

Abstract

Background: Neuroblastoma (NB) is the most common extracranial solid tumor in childhood and displays remarkable heterogeneity in clinical behaviors, ranging from spontaneous regression to rapid progression or resistance to multimodal treatment. Recent evidence has shown that microRNAs (miRNAs), a class of small non-coding RNAs, are involved in tumor development and progression. This article aimed to review recent advances in investigating the roles of miRNAs in NB.

Methods: We searched the PubMed/MEDLINE database for articles about the expression profile, functions and target genes of miRNAs in NB.

Results: We reviewed the most recent evidence regarding the functional roles of oncogenic and tumor suppressive miRNAs in NB and application of novel miRNA-based methods for diagnostic, prognostic and therapeutic purposes.

Conclusions: Deregulation of miRNAs is associated with the development and progression of NB, suggesting that miRNAs may serve as novel targets for the treatment of high-risk NB patients. However, their precise functions and underlying mechanisms still warrant further studies.

Citing Articles

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Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review).

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The MicroRNA Landscape of MYCN-Amplified Neuroblastoma.

Misiak D, Hagemann S, Bell J, Busch B, Lederer M, Bley N Front Oncol. 2021; 11:647737.

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Loss of the neurodevelopmental disease-associated gene miR-146a impairs neural progenitor differentiation and causes learning and memory deficits.

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