Implication of Non-coding RNA-mediated ROCK1 Regulation in Various Diseases

Overview

Journal Front Mol Biosci

Specialty Biology

Date 2022 Sep 30

PMID 36177350

Authors

Soudeh Ghafouri-Fard

Yadollah Poornajaf

Bashdar Mahmud Hussen

Atefe Abak

Hamed Shoorei

Mohammad Taheri

Guive Sharifi

Affiliations

Soon will be listed here.

Abstract

Rho Associated Coiled-Coil Containing Protein Kinase 1 (ROCK1) is a protein serine/threonine kinase which is activated upon binding with the GTP-bound form of Rho. This protein can modulate actin-myosin contraction and stability. Moreover, it has a crucial role in the regulation of cell polarity. Therefore, it participates in modulation of cell morphology, regulation of expression of genes, cell proliferation and differentiation, apoptotic processes as well as oncogenic processes. Recent studies have highlighted interactions between ROCK1 and several non-coding RNAs, namely microRNAs, circular RNAs and long non-coding RNAs. Such interactions can be a target of medications. In fact, it seems that the interactions are implicated in therapeutic response to several medications. In the current review, we aimed to explain the impact of these interactions in the pathoetiology of cancers as well as non-malignant disorders.

Citing Articles

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PMID: 37240338 PMC: 10219319. DOI: 10.3390/ijms24108993.

References

Meng L, Cao H, Wan C, Jiang L . MiR-539-5p alleviates sepsis-induced acute lung injury by targeting ROCK1. Folia Histochem Cytobiol. 2019; 57(4):168-178. DOI: 10.5603/FHC.a2019.0019. View

Pegoraro V, Marozzo R, Angelini C . MicroRNAs and HDAC4 protein expression in the skeletal muscle of ALS patients. Clin Neuropathol. 2020; 39(3):105-114. DOI: 10.5414/NP301233. View

Wang J, Zhang S, Li X, Gong M . LncRNA SNHG7 promotes cardiac remodeling by upregulating ROCK1 via sponging miR-34-5p. Aging (Albany NY). 2020; 12(11):10441-10456. PMC: 7346013. DOI: 10.18632/aging.103269. View

Song L, Wang L, Pan X, Yang C . lncRNA OIP5-AS1 targets ROCK1 to promote cell proliferation and inhibit cell apoptosis through a mechanism involving miR-143-3p in cervical cancer. Braz J Med Biol Res. 2020; 53(1):e8883. PMC: 6967205. DOI: 10.1590/1414-431X20198883. View

Jiang R, Zhang C, Liu G, Gu R, Wu H . MicroRNA-101 inhibits proliferation, migration and invasion in osteosarcoma cells by targeting ROCK1. Am J Cancer Res. 2017; 7(1):88-97. PMC: 5250683. View

Liu W, Shao C, Zang C, Sun J, Xu M, Wang Y . Protective effects of dexmedetomidine on cerebral ischemia/reperfusion injury via the microRNA-214/ROCK1/NF-κB axis. BMC Anesthesiol. 2021; 21(1):203. PMC: 8365892. DOI: 10.1186/s12871-021-01423-5. View

Zhu Q, Zhou Q, Dong L, Huang Z, Wu F, Deng X . MiR-199a-5p Inhibits the Growth and Metastasis of Colorectal Cancer Cells by Targeting ROCK1. Technol Cancer Res Treat. 2018; 17:1533034618775509. PMC: 5974564. DOI: 10.1177/1533034618775509. View

Fujisawa K, Fujita A, Ishizaki T, Saito Y, Narumiya S . Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase. J Biol Chem. 1996; 271(38):23022-8. DOI: 10.1074/jbc.271.38.23022. View

Zhang M, Zhang Y, Li L, Ma L, Zhou C . Dysregulation of miR-202-3p Affects Migration and Invasion of Endometrial Stromal Cells in Endometriosis via Targeting ROCK1. Reprod Sci. 2020; 27(2):731-742. DOI: 10.1007/s43032-019-00079-4. View

10.

Riento K, Ridley A . Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol. 2003; 4(6):446-56. DOI: 10.1038/nrm1128. View

11.

Yang Q, Dong Y . LncRNA SNHG20 promotes migration and invasion of ovarian cancer via modulating the microRNA-148a/ROCK1 axis. J Ovarian Res. 2021; 14(1):168. PMC: 8626962. DOI: 10.1186/s13048-021-00889-8. View

12.

Yin D, Wei G, Yang F, Sun X . Circular RNA has circ 0001591 promoted cell proliferation and metastasis of human melanoma via ROCK1/PI3K/AKT by targeting miR-431-5p. Hum Exp Toxicol. 2020; 40(2):310-324. DOI: 10.1177/0960327120950014. View

13.

Li C, Yu T, Qiu H, Zhao X, Zhou C, Qi C . miR-150 is downregulated in osteosarcoma and suppresses cell proliferation, migration and invasion by targeting ROCK1. Oncol Lett. 2017; 13(4):2191-2197. PMC: 5403695. DOI: 10.3892/ol.2017.5709. View

14.

Fan G, He Z, Cao L, Shi X, Wu S, Zhou G . miR-139 inhibits osteosarcoma cell proliferation and invasion by targeting . Front Biosci (Landmark Ed). 2019; 24(6):1167-1177. DOI: 10.2741/4773. View

15.

Luo H, Zhang Y, Qin G, Jiang B, Miao L . LncRNA MCM3AP-AS1 sponges miR-148a to enhance cell invasion and migration in small cell lung cancer. BMC Cancer. 2021; 21(1):820. PMC: 8283830. DOI: 10.1186/s12885-021-08365-8. View

16.

Zhang T, Zhang L, Han D, Tursun K, Lu X . Circular RNA hsa_Circ_101141 as a Competing Endogenous RNA Facilitates Tumorigenesis of Hepatocellular Carcinoma by Regulating miR-1297/ROCK1 Pathway. Cell Transplant. 2020; 29:963689720948016. PMC: 7563807. DOI: 10.1177/0963689720948016. View

17.

Liu F, Xiao Y, Ma L, Wang J . Regulating of cell cycle progression by the lncRNA CDKN2B-AS1/miR-324-5p/ROCK1 axis in laryngeal squamous cell cancer. Int J Biol Markers. 2020; 35(1):47-56. DOI: 10.1177/1724600819898489. View

18.

Guo D, Li Y, Chen Y, Zhang D, Wang X, Lu G . DANCR promotes HCC progression and regulates EMT by sponging miR-27a-3p via ROCK1/LIMK1/COFILIN1 pathway. Cell Prolif. 2019; 52(4):e12628. PMC: 6668976. DOI: 10.1111/cpr.12628. View

19.

Yang H, Wang Z, Wang Z . Long Noncoding RNA KCNMB2-AS1 Increases ROCK1 Expression by Sponging microRNA-374a-3p to Facilitate the Progression of Non-Small-Cell Lung Cancer. Cancer Manag Res. 2020; 12:12679-12695. PMC: 7737946. DOI: 10.2147/CMAR.S270646. View

20.

Zhong Y, Yu C, Qin W . LncRNA SNHG14 promotes inflammatory response induced by cerebral ischemia/reperfusion injury through regulating miR-136-5p /ROCK1. Cancer Gene Ther. 2018; 26(7-8):234-247. PMC: 6760557. DOI: 10.1038/s41417-018-0067-5. View