Astrovirus Pathogenesis

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2017 Jan 25

PMID 28117758

Citations 48

Authors

Cydney Johnson

Virginia Hargest

Valerie Cortez

Victoria A Meliopoulos

Stacey Schultz-Cherry

Affiliations

Soon will be listed here.

Abstract

Astroviruses are a major cause of diarrhea in the young, elderly, and the immunocompromised. Since the discovery of human astrovirus type 1 (HAstV-1) in 1975, the family has expanded to include two more human clades and numerous mammalian and avian-specific genotypes. Despite this, there is still little known about pathogenesis. The following review highlights the current knowledge of astrovirus pathogenesis, and outlines the critical steps needed to further astrovirus research, including the development of animal models of cell culture systems.

Citing Articles

Epidemiology and genetic diversity of classic human astrovirus with whole-genome sequence analysis in inpatient children under 5 years of age in Yunnan, China.

Wang Z, Jiang L, Chen L, Cun J, Zhou X, Zhou Y BMC Infect Dis. 2025; 25(1):329.

PMID: 40059161 PMC: 11892276. DOI: 10.1186/s12879-025-10708-w.

Intestinal mucus: the unsung hero in the battle against viral gastroenteritis.

Saleem W, Aslam A, Tariq M, Nauwynck H Gut Pathog. 2025; 17(1):11.

PMID: 39972475 PMC: 11841282. DOI: 10.1186/s13099-025-00684-6.

Apoptosis, inflammatory and innate immune responses induced by infection with a novel goose astrovirus in goose embryonic kidney cells.

Hou Z, Jin S, Liang Y, Wang H, Jiang D, Cao N Front Cell Infect Microbiol. 2024; 14:1452158.

PMID: 39502173 PMC: 11534606. DOI: 10.3389/fcimb.2024.1452158.

Viruses Identified in Shrews () and Their Biomedical Significance.

Gong H, Chen R, Tan S, Wang X, Chen J, Zhang Y Viruses. 2024; 16(9).

PMID: 39339918 PMC: 11437491. DOI: 10.3390/v16091441.

Prospects for the use of viral proteins for the construction of chimeric toxins.

Novikov D, Vasilchikova E, Vasilchikov P Arch Virol. 2024; 169(10):208.

PMID: 39327316 DOI: 10.1007/s00705-024-06139-8.

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