Increased Incidence of Ectopic Pregnancy After in Vitro Fertilization in Women with Decreased Ovarian Reserve

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Jan 19

PMID 28099907

Citations 7

Authors

Shengli Lin

Rui Yang

Hongbin Chi

Ying Lian

Jiejing Wang

Shuo Huang

Cuiling Lu

Ping Liu

Jie Qiao

Affiliations

Soon will be listed here.

Abstract

The incidence of ectopic pregnancy after assisted reproductive technology is increased approximately 2.5-5-fold compared with natural conceptions.Strategies were used to decrease the incidence of ectopic pregnancy, but ectopic pregnancy still occurs. In the present study, women were selected with decreased ovarian reserve (defined as FSH > 10 IU/L) aged 20 to 38 years who underwent IVF-ET between 2009 and 2014. These 2,061 women were age-matched with an equal number of women with normal ovarian reserve (defined as FSH ≤ 10 IU/L). During cycles following fresh embryo transfer, 93 patients were diagnosed with ectopic pregnancy. The incidence of ectopic pregnancy in clinical pregnancies was significantly higher in the decreased ovarian reserve than in the normal ovarian reserve group (5.51% vs. 2.99%). After adjusting for confounding factors, the incidence of ectopic pregnancy was significantly associated with decreased ovarian reserve. Our results showed that decreased ovarian reserve is an independent risk factor for ectopic pregnancy after in vitro fertilization-embryo transfer.

Citing Articles

The Mechanistic Study of Mitochondrial Autophagy and Ferroptosis in the Progression of Decreased Ovarian Reserve.

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Effects of flaxseed oil supplementation on metaphase II oocyte rates in IVF cycles with decreased ovarian reserve: a randomized controlled trial.

Chu Q, Yu Y, Zhang J, Zhang Y, Yu J Front Endocrinol (Lausanne). 2024; 15:1280760.

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Mechanism Research of DHEA Treatment Improving Diminished Ovarian Reserve by Attenuating the AMPK-SIRT1 Signaling and Mitophagy.

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Risk factors of ectopic pregnancy after in vitro fertilization-embryo transfer in Chinese population: A meta-analysis.

Wang Y, Chen L, Tao Y, Luo M PLoS One. 2024; 19(1):e0296497.

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The effect of sperm DNA fragmentation on the incidence and origin of whole and segmental chromosomal aneuploidies in human embryos.

Gao J, Yan Z, Yan L, Zhu X, Jiang H, Qiao J Reproduction. 2023; 166(2):117-124.

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