Correlation Between Ovarian Reserve and Incidence of Ectopic Pregnancy After Fertilization and Embryo Transfer

Overview

Journal Yonsei Med J

Specialty General Medicine

Date 2019 Feb 26

PMID 30799591

Citations 7

Authors

Sung Woo Kim

Yong Jin Kim

Jung Ho Shin

Hoon Kim

Seung Yup Ku

Chang Suk Suh

Seok Hyun Kim

Young Min Choi

Affiliations

Soon will be listed here.

Abstract

Purpose: To elucidate the correlation between ovarian reserve and the incidence of ectopic pregnancy (EP) following in vitro fertilization and embryo transfer (IVF/ET) cycles.

Materials And Methods: In this observational study, 430 fresh IVF/ET cycles were examined from patient data of two university hospital infertility clinics. All included patients were positive for β-human chorionic gonadotropin (hCG) at 2 weeks after oocyte retrieval via controlled ovarian stimulation. For each cycle, information on age, duration of infertility, basal follicle stimulating hormone (FSH), anti-Müllerian hormone (AMH), days of ovarian stimulation, numbers of retrieved oocytes and transferred embryos, and pregnancy outcomes was collected. Patients with AMH lower than 1.0 ng/dL or basal FSH higher than 10 mIU/mL were classified into the decreased ovarian reserve (DOR) group, and the remaining patients were classified into the normal ovarian reserve (NOR) group.

Results: In total, 355 cycles showed NOR, and 75 cycles DOR. There were no significant differences between the DOR and NOR groups regarding intrauterine (74.7% vs. 83.4%, respectively) or chemical (14.7% vs. 14.1%, respectively) pregnancies. The DOR group had a higher EP than that of NOR group [10.7% (8/75) vs. 2.5% (9/355), =0.004]. In both univariate [odds ratio (OR) 5.6, 95% confidence interval (CI) 1.4-9.6, =0.011] and multivariate (adjusted OR 5.1, 95 % CI 1.1-18.7, =0.012) analysis, DOR was associated with a higher risk of EP.

Conclusion: DOR may be associated with a higher risk of EP in IVF/ET cycles with controlled ovarian stimulation. More careful monitoring may be necessary for pregnant women with DOR.

Citing Articles

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Risk factors of ectopic pregnancy after in vitro fertilization-embryo transfer in Chinese population: A meta-analysis.

Wang Y, Chen L, Tao Y, Luo M PLoS One. 2024; 19(1):e0296497.

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He Y, Liu L, Yao F, Sun C, Meng M, Lan Y Front Endocrinol (Lausanne). 2023; 14:1086924.

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Ectopic pregnancy risk factors in infertile patients: a 10-year single center experience.

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