Increased Maternal HCG Concentrations in Early in Vitro Pregnancy with Elevated Basal FSH

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Sep 11

PMID 30199550

Authors

Xiao Han

Baoli Yin

Shengli Lin

Qian Wang

Ni Su

Cuilian Zhang

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate factors that influence maternal hCG concentration in early pregnancy and the relationship between hCG concentration in early pregnancy and basal FSH (bFSH) level.

Design: Retrospective cohort study.

Setting: Reproductive medical center.

Patient(s): In total, 482 women aged 22 to 38 years with elevated basal FSH (> 10 IU/L) and who experienced a single live birth after in vitro fertilization-embryo transfer were selected. These 482 women were age-matched with an equal number of women with normal basal FSH (≤10 IU/L) who also experienced a single live birth.

Intervention(s): None.

Main Outcome Measure(s): HCG concentration.

Result(s): The hCG concentrations on Day 14 and Day 21 were 560.46 (363.63-842.52) IU/L and 9862.00 (6512.25-14029.50) IU/L, respectively, in the elevated bFSH group, and these values were significantly increased compared with the normal bFSH group. After adjusting for confounding factors, the concentrations of maternal hCG on Day 14 and Day 21 were significantly associated with basal FSH. In addition, crude linear regression analysis demonstrated that hCG concentrations increased as the basal serum levels of FSH increased.

Conclusion(s): Elevated basal FSH has implications for the interpretation of hCG concentrations in early pregnancy after in vitro fertilization-embryo transfer (IVF-ET) that led to a single live birth.

References

Zimmermann G, Ackermann W, Alexander H . Expression and production of human chorionic gonadotropin (hCG) in the normal secretory endometrium: evidence of CGB7 and/or CGB6 beta hCG subunit gene expression. Biol Reprod. 2011; 86(3):87. DOI: 10.1095/biolreprod.111.092429. View

Coticchio G, Dal Canto M, Mignini Renzini M, Guglielmo M, Brambillasca F, Turchi D . Oocyte maturation: gamete-somatic cells interactions, meiotic resumption, cytoskeletal dynamics and cytoplasmic reorganization. Hum Reprod Update. 2015; 21(4):427-54. DOI: 10.1093/humupd/dmv011. View

Asvold B, Vatten L, Tanbo T, Eskild A . Concentrations of human chorionic gonadotrophin in very early pregnancy and subsequent pre-eclampsia: a cohort study. Hum Reprod. 2014; 29(6):1153-60. DOI: 10.1093/humrep/deu068. View

Detti L, Mitwally M, Rode A, Yelian F, Kruger M, Diamond M . Serum human chorionic gonadotropin level after ovulation triggering is influenced by the patient's body mass index and the number of larger follicles. Fertil Steril. 2007; 88(1):152-5. DOI: 10.1016/j.fertnstert.2006.11.124. View

Hu W, Feng Z, Teresky A, Levine A . p53 regulates maternal reproduction through LIF. Nature. 2007; 450(7170):721-4. DOI: 10.1038/nature05993. View

Oron G, Esh-Broder E, Son W, Holzer H, Tulandi T . Predictive value of maternal serum human chorionic gonadotropin levels in pregnancies achieved by in vitro fertilization with single cleavage and single blastocyst embryo transfers. Fertil Steril. 2015; 103(6):1526-31.e1-2. DOI: 10.1016/j.fertnstert.2015.02.028. View

Lin S, Li M, Lian Y, Chen L, Liu P . No effect of embryo culture media on birthweight and length of newborns. Hum Reprod. 2013; 28(7):1762-7. DOI: 10.1093/humrep/det095. View

Singh N, Begum A, Malhotra N, Bahadur A, Vanamail P . Role of early serum beta human chorionic gonadotropin measurement in predicting multiple pregnancy and pregnancy wastage in an in vitro ET fertilization cycle. J Hum Reprod Sci. 2013; 6(3):213-8. PMC: 3853879. DOI: 10.4103/0974-1208.121425. View

Schufreider A, McQueen D, Lee S, Allon R, Uhler M, Davie J . Diminished ovarian reserve is not observed in infertility patients with high normal CGG repeats on the fragile X mental retardation 1 (FMR1) gene. Hum Reprod. 2015; 30(11):2686-92. DOI: 10.1093/humrep/dev220. View

10.

Sung N, Kwak-Kim J, Koo H, Yang K . Serum hCG-β levels of postovulatory day 12 and 14 with the sequential application of hCG-β fold change significantly increased predictability of pregnancy outcome after IVF-ET cycle. J Assist Reprod Genet. 2016; 33(9):1185-94. PMC: 5010803. DOI: 10.1007/s10815-016-0744-y. View

11.

Laptenko O, Prives C . p53: master of life, death, and the epigenome. Genes Dev. 2017; 31(10):955-956. PMC: 5495123. DOI: 10.1101/gad.302364.117. View

12.

Lin S, Yang R, Chi H, Lian Y, Wang J, Huang S . Increased incidence of ectopic pregnancy after in vitro fertilization in women with decreased ovarian reserve. Oncotarget. 2017; 8(9):14570-14575. PMC: 5362426. DOI: 10.18632/oncotarget.14679. View

13.

Pacella L, Zander-Fox D, Armstrong D, Lane M . Women with reduced ovarian reserve or advanced maternal age have an altered follicular environment. Fertil Steril. 2012; 98(4):986-94.e1-2. DOI: 10.1016/j.fertnstert.2012.06.025. View

14.

Tanbo T, Eskild A . Maternal hCG concentrations in early IVF pregnancies: associations with number of cells in the Day 2 embryo and oocytes retrieved. Hum Reprod. 2015; 30(12):2758-63. DOI: 10.1093/humrep/dev269. View

15.

Lin S, Li R, Chi H, Huang S, Zhang H, Zheng X . Effect of ABO blood type on ovarian reserve in Chinese women. Fertil Steril. 2014; 102(6):1729-32.e2. DOI: 10.1016/j.fertnstert.2014.09.008. View

16.

Esh-Broder E, Oron G, Son W, Holzer H, Tulandi T . Early maternal serum ß-human chorionic gonadotropin (ß-hCG) levels and sex-related growth difference of IVF embryos. J Assist Reprod Genet. 2015; 32(10):1491-5. PMC: 4615924. DOI: 10.1007/s10815-015-0550-y. View

17.

Gilchrist R, Lane M, Thompson J . Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality. Hum Reprod Update. 2008; 14(2):159-77. DOI: 10.1093/humupd/dmm040. View

18.

Dewailly D, Andersen C, Balen A, Broekmans F, Dilaver N, Fanchin R . The physiology and clinical utility of anti-Mullerian hormone in women. Hum Reprod Update. 2014; 20(3):370-85. DOI: 10.1093/humupd/dmt062. View

19.

Eskild A, Fedorcsak P, Morkrid L, Tanbo T . Maternal body mass index and serum concentrations of human chorionic gonadotropin in very early pregnancy. Fertil Steril. 2012; 98(4):905-10. DOI: 10.1016/j.fertnstert.2012.06.011. View

20.

Jahromi B, Sadeghi S, Alipour S, Parsanezhad M, Alamdarloo S . Effect of Melatonin on the Outcome of Assisted Reproductive Technique Cycles in Women with Diminished Ovarian Reserve: A Double-Blinded Randomized Clinical Trial. Iran J Med Sci. 2017; 42(1):73-78. PMC: 5337768. View