Mapping Complementary Features of Cross-species Structural Connectivity to Construct Realistic "Virtual Brains"

Overview

Journal Hum Brain Mapp

Publisher Wiley

Specialty Neurology

Date 2017 Jan 6

PMID 28054725

Citations 11

Authors

Gleb Bezgin

Ana Solodkin

Rembrandt Bakker

Petra Ritter

Anthony R McIntosh

Affiliations

Soon will be listed here.

Abstract

Modern systems neuroscience increasingly leans on large-scale multi-lab neuroinformatics initiatives to provide necessary capacity for biologically realistic modeling of primate whole-brain activity. Here, we present a framework to assemble primate brain's biologically plausible anatomical backbone for such modeling initiatives. In this framework, structural connectivity is determined by adding complementary information from invasive macaque axonal tract tracing and non-invasive human diffusion tensor imaging. Both modalities are combined by means of available interspecies registration tools and a newly developed Bayesian probabilistic modeling approach to extract common connectivity evidence. We demonstrate how this novel framework is embedded in the whole-brain simulation platform called The Virtual Brain (TVB). Hum Brain Mapp 38:2080-2093, 2017. © 2017 Wiley Periodicals, Inc.

Citing Articles

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Cross-species alignment along the chronological axis reveals evolutionary effect on structural development of the human brain.

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