Effects of Heartbeat and Respiration on Macaque FMRI: Implications for Functional Connectivity

Overview

Journal Neuropsychologia

Specialties Neurology
Psychology

Date 2009 Dec 9

PMID 19969009

Citations 18

Authors

Tobias Teichert

Jack Grinband

Joy Hirsch

Vincent P Ferrera

Affiliations

Soon will be listed here.

Abstract

The use of functional magnetic resonance imaging (fMRI) in non-human primates is on the increase. It is known that the blood-oxygen-level-dependent (BOLD) signal varies not only as a function of local neuronal energy consumption but also as a function of cardiac and respiratory activity. We mapped these cyclic cardiac and respiratory artifacts in anesthetized macaque monkeys and present an objective analysis of their impact on estimates of functional connectivity (fcMRI). Voxels with significant cardiac and respiratory artifacts were found in much the same regions as previously reported for awake humans. We show two example seeds where removing the artifacts clearly decreased the number of false positive and false negative correlations. In particular, removing the artifacts reduced correlations in the so-called resting state network. Temporal bandpass filtering or spatial smoothing may help to reduce the effects of artifacts in some cases but are not an adequate replacement for an algorithm that explicitly models and removes cyclic cardiac and respiratory artifacts.

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