The Role of Aneuploidy in Cancer Evolution

Overview

Journal Cold Spring Harb Perspect Med

Specialty General Medicine

Date 2017 Jan 5

PMID 28049655

Citations 132

Authors

Laurent Sansregret

Charles Swanton

Affiliations

Soon will be listed here.

Abstract

Chromosomal aberrations during cell division represent one of the first recognized features of human cancer cells, and modern detection methods have revealed the pervasiveness of aneuploidy in cancer. The ongoing karyotypic changes brought about by chromosomal instability (CIN) contribute to tumor heterogeneity, drug resistance, and treatment failure. Whole-chromosome and segmental aneuploidies resulting from CIN have been proposed to allow "macroevolutionary" leaps that may contribute to profound phenotypic change. In this review, we will outline evidence indicating that aneuploidy and CIN contribute to cancer evolution.

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