Aneuploidy and Complex Genomic Rearrangements in Cancer Evolution

Overview

Journal Nat Cancer

Specialty Oncology

Date 2024 Jan 29

PMID 38286829

Authors

Toby M Baker

Sara Waise

Maxime Tarabichi

Peter Van Loo

Affiliations

Soon will be listed here.

Abstract

Mutational processes that alter large genomic regions occur frequently in developing tumors. They range from simple copy number gains and losses to the shattering and reassembly of entire chromosomes. These catastrophic events, such as chromothripsis, chromoplexy and the formation of extrachromosomal DNA, affect the expression of many genes and therefore have a substantial effect on the fitness of the cells in which they arise. In this review, we cover large genomic alterations, the mechanisms that cause them and their effect on tumor development and evolution.

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