Effects of Yohimbine on Submaxillary Salivation in Dogs

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1989 Sep 1

PMID 2804539

Citations 10

Authors

P MONTASTRUC

M Berlan

J L Montastruc

Affiliations

Soon will be listed here.

Abstract

1. The effects of yohimbine (0.5 mg kg-1 i.v.) on both resting and parasympathetic and sympathetic stimulation-induced submaxillary salivary responses were investigated in the anaesthetized dog. 2. Salivary secretion was increased significantly for a period of 45 min following an injection of yohimbine. 3. Sectioning of the chorda tympani (but not the cervical sympathetic) nerve abolished the yohimbine-induced increase in resting salivary secretion and potentiated that elicited by electrical stimulation of the chorda tympani nerve. 4. These results show that yohimbine increases submaxillary secretion by inhibition of presynaptic alpha 2-adrenoceptors located on the chorda tympani, which inhibit cholinergic transmission.

Citing Articles

Artificial Saliva for Therapeutic Management of Xerostomia: A Narrative Review.

Alhejoury H, Mogharbel L, Al-Qadhi M, Shamlan S, Alturki A, Babatin W J Pharm Bioallied Sci. 2022; 13(Suppl 2):S903-S907.

PMID: 35017895 PMC: 8686887. DOI: 10.4103/jpbs.jpbs_236_21.

Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part II: physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans.

Samuels E, Szabadi E Curr Neuropharmacol. 2009; 6(3):254-85.

PMID: 19506724 PMC: 2687931. DOI: 10.2174/157015908785777193.

Effects of physiological and pharmacological variation of sympathetic nervous system activity on plasma non-esterified fatty acid concentrations in man.

Barbe P, Galitzky J, Riviere D, Senard J, Lafontan M, Garrigues M Br J Clin Pharmacol. 1993; 36(1):25-30.

PMID: 8373709 PMC: 1364550. DOI: 10.1111/j.1365-2125.1993.tb05887.x.

Pharmacokinetic study of yohimbine and its pharmacodynamic effects on salivary secretion in patients treated with tricyclic antidepressants.

Bagheri H, Picault P, Schmitt L, Houin G, Berlan M, Montastruc J Br J Clin Pharmacol. 1994; 37(1):93-6.

PMID: 8148228 PMC: 1364719. DOI: 10.1111/j.1365-2125.1994.tb04248.x.

Mechanisms of sympathetic enhancement and inhibition of parasympathetically induced salivary secretion in anaesthetized dogs.

Lung M Br J Pharmacol. 1994; 112(2):411-6.

PMID: 8075858 PMC: 1910338. DOI: 10.1111/j.1476-5381.1994.tb13087.x.

References

Goldberg M, Robertson D . Yohimbine: a pharmacological probe for study of the alpha 2-adrenoreceptor. Pharmacol Rev. 1983; 35(3):143-80. View

Armstrong J, Scatton B, Cavero I . Urethane inhibits cardiovascular responses mediated by the stimulation of alpha-2 adrenoceptors in the rat. J Pharmacol Exp Ther. 1982; 223(2):524-35. View

Kaniucki M, STEFANO F, Perec C . Clonidine inhibits salivary secretion by activation of postsynaptic alpha 2-receptors. Naunyn Schmiedebergs Arch Pharmacol. 1984; 326(4):313-6. DOI: 10.1007/BF00501435. View

Moore N, Chadelaud M, Huchet A, Saligaut C, Daoust M, Lhuintre J . Urethane interferes with the alpha 2-agonist guanfacine. J Cardiovasc Pharmacol. 1984; 6(5):973-4. DOI: 10.1097/00005344-198409000-00036. View

Kaniucki M, Elverdin J, STEFANO F, Perec C . Effects of guanabenz and guanfacine on postsynaptic alpha 2-adrenoceptors in the rat submaxillary and parotid glands. Naunyn Schmiedebergs Arch Pharmacol. 1985; 329(3):289-92. DOI: 10.1007/BF00501882. View

Terzic M, Stojic D . The inhibitory effect of guanabenz on submandibulary salivation induced by chorda tympani stimulation in anaesthetized cat. J Pharmacol. 1986; 17(4):671-5. View

Owen J, Nakatsu S, Fenemore J, Condra M, SURRIDGE D, Morales A . The pharmacokinetics of yohimbine in man. Eur J Clin Pharmacol. 1987; 32(6):577-82. DOI: 10.1007/BF02455991. View

Taouis M, Berlan M, MONTASTRUC P, Lafontan M . Mechanism of the lipid-mobilizing effect of alpha-2 adrenergic antagonists in the dog. J Pharmacol Exp Ther. 1988; 247(3):1172-80. View

Langer S . Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. Br J Pharmacol. 1977; 60(4):481-97. PMC: 1667392. DOI: 10.1111/j.1476-5381.1977.tb07526.x. View

10.

GREEN G, Wilson H, Yates M . The effect of clonidine on centrally and peripherally evoked submaxillary salivation. Eur J Pharmacol. 1979; 53(3):297-300. DOI: 10.1016/0014-2999(79)90136-5. View

11.

GREEN G, Wilson H, Yates M . The mechanism of the clonidine-induced reduction in peripheral parasympathetic submaxillary salivation. Eur J Pharmacol. 1979; 56(4):331-6. DOI: 10.1016/0014-2999(79)90263-2. View

12.

Bylund D, Martinez J . alpha 2-Adrenergic receptors appear in rat salivary glands after reserpine treatment. Nature. 1980; 285(5762):229-30. DOI: 10.1038/285229a0. View

13.

Bylund D, Martinez J . Postsynaptic localization of alpha 2-adrenergic receptors in rat submandibular gland. J Neurosci. 1981; 1(9):1003-7. PMC: 6564104. View

14.

Langer S, Shepperson N . Prejunctional modulation of noradrenaline release by alpha 2-adrenoceptors: physiological and pharmacological implications in the cardiovascular system. J Cardiovasc Pharmacol. 1982; 4 Suppl 1:S35-40. View

15.

Martinez J, Bylund D, Camden J . Characterization of autonomic receptors in the rat sublingual gland by biochemical and radioligand assays. Naunyn Schmiedebergs Arch Pharmacol. 1982; 318(4):313-8. DOI: 10.1007/BF00501171. View

16.

Elverdin J, STEFANO F, Perec C . Alpha-1 adrenoceptors mediate secretory responses to norepinephrine in innervated and denervated rat submaxillary glands. J Pharmacol Exp Ther. 1984; 229(1):261-6. View