The Effect of Clonidine on Centrally and Peripherally Evoked Submaxillary Salivation
Overview
Affiliations
In anaesthetised cats, clonidine (10 microgram/kg, i.v.) produced a 60% reduction in submaxillary salivation induced by brain stem stimulation at 10 and 15 Hz and reductions of 35 and 15% in salivation evoked by chorda tympani nerve stimulation at 5 and 15 Hz respectively. Pretreatment with clonidine (20 microgram/kg/day, orally) for 28 days reduced peripherally evoked salivation by 45%. These results suggest that both central and peripheral mechanisms are involved in the diminished salivation produced by clonidine, and the reduction on peripheral stimulation may reflect the presence of presynaptic alpha-adrenoceptors inhibiting cholinergic transmission.
Does preoperative oral clonidine inhibit salivary secretion during general anesthesia?.
Numazawa R, Mayumi T, Kemmotsu O J Anesth. 1993; 7(3):297-302.
PMID: 15278815 DOI: 10.1007/s0054030070297.
Szabo B, Fritz T, Wedzony K Br J Pharmacol. 2001; 134(2):295-304.
PMID: 11564647 PMC: 1572948. DOI: 10.1038/sj.bjp.0704237.
Ernsberger P, Haxhiu M, Graff L, Collins L, Dreshaj I, Grove D Cardiovasc Drugs Ther. 1994; 8 Suppl 1:27-41.
PMID: 8068578 DOI: 10.1007/BF00877082.
Influence of clonidine on experimental hypertension induced by cholinergic stimulation.
Buccafusco J, Spector S Experientia. 1980; 36(6):671-3.
PMID: 7418828 DOI: 10.1007/BF01970131.
Clonidine inhibits salivary secretion by activation of postsynaptic alpha 2-receptors.
Kaniucki M, STEFANO F, Perec C Naunyn Schmiedebergs Arch Pharmacol. 1984; 326(4):313-6.
PMID: 6207441 DOI: 10.1007/BF00501435.