Engineering of Brome Mosaic Virus for Biomedical Applications

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2016 Dec 27

PMID 28018580

Citations 16

Authors

Ibrahim Yildiz

Irina Tsvetkova

Amy M Wen

Sourabh Shukla

M Hema Masarapu

Bogdan Dragnea

Nicole F Steinmetz

Affiliations

Soon will be listed here.

Abstract

Viral nanoparticles (VNPs) are becoming versatile tools in platform technology development. Their well-defined structures as well as their programmability through chemical and genetic modification allow VNPs to be engineered for potential imaging and therapeutic applications. In this article, we report the application of a variety of bioconjugation chemistries to the plant VNP (BMV). Functional BMV nanoparticles displaying multiple copies of fluorescent dyes, PEG molecules, chemotherapeutic drug moieties, targeting proteins and cell penetrating peptides were formulated. This opens the door for the application of BMV in nanomedicine.

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References

Destito G, Yeh R, Rae C, Finn M, Manchester M . Folic acid-mediated targeting of cowpea mosaic virus particles to tumor cells. Chem Biol. 2007; 14(10):1152-62. PMC: 2293326. DOI: 10.1016/j.chembiol.2007.08.015. View

Wang Q, Lin T, Johnson J, Finn M . Natural supramolecular building blocks. Cysteine-added mutants of cowpea mosaic virus. Chem Biol. 2002; 9(7):813-9. DOI: 10.1016/s1074-5521(02)00166-7. View

Singh P, Prasuhn D, Yeh R, Destito G, Rae C, Osborn K . Bio-distribution, toxicity and pathology of cowpea mosaic virus nanoparticles in vivo. J Control Release. 2007; 120(1-2):41-50. PMC: 2849971. DOI: 10.1016/j.jconrel.2007.04.003. View

Udit A, Brown S, Baksh M, Finn M . Immobilization of bacteriophage Qbeta on metal-derivatized surfaces via polyvalent display of hexahistidine tags. J Inorg Biochem. 2008; 102(12):2142-6. DOI: 10.1016/j.jinorgbio.2008.08.003. View

Sun J, Dufort C, Daniel M, Murali A, Chen C, Gopinath K . Core-controlled polymorphism in virus-like particles. Proc Natl Acad Sci U S A. 2007; 104(4):1354-9. PMC: 1783121. DOI: 10.1073/pnas.0610542104. View

Brunel F, Lewis J, Destito G, Steinmetz N, Manchester M, Stuhlmann H . Hydrazone ligation strategy to assemble multifunctional viral nanoparticles for cell imaging and tumor targeting. Nano Lett. 2010; 10(3):1093-7. PMC: 3988696. DOI: 10.1021/nl1002526. View

Steinmetz N, Cho C, Ablack A, Lewis J, Manchester M . Cowpea mosaic virus nanoparticles target surface vimentin on cancer cells. Nanomedicine (Lond). 2011; 6(2):351-64. PMC: 3436905. DOI: 10.2217/nnm.10.136. View

Huang X, Bronstein L, Retrum J, Dufort C, Tsvetkova I, Aniagyei S . Self-assembled virus-like particles with magnetic cores. Nano Lett. 2007; 7(8):2407-16. DOI: 10.1021/nl071083l. View

Zhao Q, Chen W, Chen Y, Zhang L, Zhang J, Zhang Z . Self-assembled virus-like particles from rotavirus structural protein VP6 for targeted drug delivery. Bioconjug Chem. 2011; 22(3):346-52. DOI: 10.1021/bc1002532. View

10.

Daniel M, Tsvetkova I, Quinkert Z, Murali A, De M, Rotello V . Role of surface charge density in nanoparticle-templated assembly of bromovirus protein cages. ACS Nano. 2010; 4(7):3853-60. PMC: 2937271. DOI: 10.1021/nn1005073. View

11.

Lucas R, Larson S, McPherson A . The crystallographic structure of brome mosaic virus. J Mol Biol. 2002; 317(1):95-108. DOI: 10.1006/jmbi.2001.5389. View

12.

Hema M, Murali A, Ni P, Vaughan R, Fujisaki K, Tsvetkova I . Effects of amino-acid substitutions in the Brome mosaic virus capsid protein on RNA encapsidation. Mol Plant Microbe Interact. 2010; 23(11):1433-47. DOI: 10.1094/MPMI-05-10-0118. View

13.

Ahlquist P, Luckow V, Kaesberg P . Complete nucleotide sequence of brome mosaic virus RNA3. J Mol Biol. 1981; 153(1):23-38. DOI: 10.1016/0022-2836(81)90524-6. View

14.

Pokorski J, Steinmetz N . The art of engineering viral nanoparticles. Mol Pharm. 2010; 8(1):29-43. PMC: 3156490. DOI: 10.1021/mp100225y. View

15.

Liu T, Kirn D . Gene therapy progress and prospects cancer: oncolytic viruses. Gene Ther. 2008; 15(12):877-84. DOI: 10.1038/gt.2008.72. View

16.

Medintz I, Sapsford K, Konnert J, Chatterji A, Lin T, Johnson J . Decoration of discretely immobilized cowpea mosaic virus with luminescent quantum dots. Langmuir. 2005; 21(12):5501-10. DOI: 10.1021/la0468287. View

17.

Gatter K, Brown G, Trowbridge I, Woolston R, Mason D . Transferrin receptors in human tissues: their distribution and possible clinical relevance. J Clin Pathol. 1983; 36(5):539-45. PMC: 498283. DOI: 10.1136/jcp.36.5.539. View

18.

Strable E, Finn M . Chemical modification of viruses and virus-like particles. Curr Top Microbiol Immunol. 2009; 327:1-21. DOI: 10.1007/978-3-540-69379-6_1. View

19.

Steinmetz N, Hong V, Spoerke E, Lu P, Breitenkamp K, Finn M . Buckyballs meet viral nanoparticles: candidates for biomedicine. J Am Chem Soc. 2009; 131(47):17093-5. PMC: 2797550. DOI: 10.1021/ja902293w. View

20.

Pokorski J, Breitenkamp K, Liepold L, Qazi S, Finn M . Functional virus-based polymer-protein nanoparticles by atom transfer radical polymerization. J Am Chem Soc. 2011; 133(24):9242-5. PMC: 3163106. DOI: 10.1021/ja203286n. View