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Sourabh Shukla

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Articles 59
Citations 1936
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Recent Articles
1.
Zhao Z, Xiang Y, Koellhoffer E, Shukla S, Fiering S, Chen S, et al.
Mater Adv . 2024 Feb; 5(4):1480-1486. PMID: 38380337
Implantable polymeric hydrogels loaded with immunostimulatory cowpea mosaic virus (CPMV) were fabricated using digital light processing (DLP) printing technology. The CPMV-laden hydrogels were surgically implanted into the peritoneal cavity to...
2.
de Oliveira J, Zhao Z, Xiang Y, Shin M, Villasenor K, Deng X, et al.
Front Microbiol . 2023 May; 14:1117494. PMID: 37152732
The COVID-19 pandemic caused by SARS-CoV-2 sparked intensive research into the development of effective vaccines, 50 of which have been approved thus far, including the novel mRNA-based vaccines developed by...
3.
Ghani M, Bangar A, Yang Y, Jung E, Sauceda C, Mandt T, et al.
J Vasc Interv Radiol . 2023 Mar; 34(7):1247-1257.e8. PMID: 36997021
Purpose: To test the hypothesis that cryoablation combined with intratumoral immunomodulating nanoparticles from cowpea mosaic virus (CPMV) as an in situ vaccination approach induces systemic antitumoral immunity in a murine...
4.
Chung Y, Church D, Koellhoffer E, Osota E, Shukla S, Rybicki E, et al.
Nat Rev Mater . 2021 Dec; 7(5):372-388. PMID: 34900343
Biologics - medications derived from a biological source - are increasingly used as pharmaceuticals, for example, as vaccines. Biologics are usually produced in bacterial, mammalian or insect cells. Alternatively, plant...
5.
Ortega-Rivera O, Shukla S, Shin M, Chen A, Beiss V, Moreno-Gonzalez M, et al.
ACS Infect Dis . 2021 Oct; 7(11):3096-3110. PMID: 34672530
The development of vaccines against coronaviruses has focused on the spike (S) protein, which is required for the recognition of host-cell receptors and thus elicits neutralizing antibodies. Targeting conserved epitopes...
6.
Nkanga C, Chung Y, Shukla S, Zhou J, Jokerst J, Steinmetz N
Biomater Sci . 2021 Sep; 9(21):7134-7150. PMID: 34591046
Plant virus nanoparticles (VNPs) have multiple advantages over their synthetic counterparts including the cost-effective large-scale manufacturing of uniform particles that are easy to functionalize. Tobacco mosaic virus (TMV) is one...
7.
Patel B, Wang C, Lorens B, Levine A, Steinmetz N, Shukla S
ACS Appl Bio Mater . 2021 Aug; 3(7):4179-4187. PMID: 34368641
Cancer vaccines are promising adjuvant immunotherapies that can stimulate the immune system to recognize tumor-associated antigens and eliminate the residual or recurring disease. The aberrant and restricted expression of highly...
8.
Cai H, Shukla S, Steinmetz N
Adv Funct Mater . 2021 Aug; 30(15). PMID: 34366757
Oligodeoxynucleotides (ODNs) with CpG motifs have potent immunostimulatory effects on many subsets of immune cells. For example, Class B CpG-ODNs, such as ODN1826 induce the phagocytic activity of macrophages by...
9.
Shukla S, Marks I, Church D, Chan S, Pokorski J, Steinmetz N
RSC Adv . 2021 Jun; 11(33):20101-20108. PMID: 34178308
Prostate-specific membrane antigen (PSMA) is a membrane-bound protein that is preferentially expressed in the prostate gland and induced in many prostate cancers, making it an important target for new diagnostics...
10.
Boone C, Wang C, Lopez-Ramirez M, Beiss V, Shukla S, Chariou P, et al.
ACS Appl Nano Mater . 2021 May; 3(8):8037-8051. PMID: 33969278
The solid tumor microenvironment (TME) poses a significant structural and biochemical barrier to immunotherapeutic agents. To address the limitations of tumor penetration and distribution, and to enhance antitumor efficacy of...