Antioxidant Effects of Curcuminoids in Patients with Type 2 Diabetes Mellitus: a Randomized Controlled Trial

Overview

Journal Inflammopharmacology

Specialty Pharmacology

Date 2016 Dec 9

PMID 27928704

Citations 71

Authors

Yunes Panahi

Nahid Khalili

Ebrahim Sahebi

Soha Namazi

Maryam Saberi Karimian

Muhammed Majeed

Amirhossein Sahebkar

Affiliations

Soon will be listed here.

Abstract

Background: Oxidative stress has a key role in the pathogenesis of type II diabetes mellitus (T2DM) and its vascular complications. Antioxidant therapy has been suggested as a potential approach to blunt T2DM development and progression. The aim of this study was to assess the effects of supplementation with curcuminoids, which are natural polyphenolics from turmeric, on oxidative indices in diabetic individuals.

Methods: In this randomized double-blind placebo-controlled trial, 118 subjects with T2DM were randomized to curcuminoids (1000 mg/day co-administered with piperine 10 mg/day) or matching placebo for a period of 8 weeks. Serum total antioxidant capacity, superoxide dismutase (SOD) activities and malondialdehyde (MDA) concentrations were measured at baseline and after the supplementation period.

Results: Curcuminoids supplementation caused a significant elevation in serum total antioxidant capacity (TAC) (p < 0.001) and SOD activities (p < 0.001), while serum MDA levels were significantly reduced compared with the placebo group (p < 0.001). These results remained statistically significant after adjustment for potential confounders (baseline differences in body mass index and fasting serum insulin).

Conclusion: The present results support an antioxidant effect of curcuminoids supplementation in patients with T2DM, and call for future studies to assess the impact of these antioxidant effects on the occurrence of diabetic complications and cardiovascular endpoints.

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References

Panahi Y, Ghanei M, Hajhashemi A, Sahebkar A . Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard: A Randomized Controlled Trial. J Diet Suppl. 2014; 13(1):93-105. DOI: 10.3109/19390211.2014.952865. View

Poitout V, Robertson R . Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev. 2007; 29(3):351-66. PMC: 2528858. DOI: 10.1210/er.2007-0023. View

Momtazi A, Sahebkar A . Difluorinated Curcumin: A Promising Curcumin Analogue with Improved Anti-Tumor Activity and Pharmacokinetic Profile. Curr Pharm Des. 2016; 22(28):4386-97. DOI: 10.2174/1381612822666160527113501. View

Sahebkar A . Curcuminoids for the management of hypertriglyceridaemia. Nat Rev Cardiol. 2014; 11(2):123. DOI: 10.1038/nrcardio.2013.140-c1. View

Biswas J, Sinha D, Mukherjee S, Roy S, Siddiqi M, Roy M . Curcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal. Hum Exp Toxicol. 2010; 29(6):513-24. DOI: 10.1177/0960327109359020. View

Panahi Y, Sahebkar A, Amiri M, Davoudi S, Beiraghdar F, Hoseininejad S . Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2011; 108(7):1272-9. DOI: 10.1017/S0007114511006544. View

Zhou H, Beevers C, Huang S . The targets of curcumin. Curr Drug Targets. 2010; 12(3):332-47. PMC: 3025067. DOI: 10.2174/138945011794815356. View

Khonche A, Biglarian O, Panahi Y, Valizadegan G, Soflaei S, Ghamarchehreh M . Adjunctive Therapy with Curcumin for Peptic Ulcer: a Randomized Controlled Trial. Drug Res (Stuttg). 2016; 66(8):444-8. DOI: 10.1055/s-0042-109394. View

Momtazi A, Shahabipour F, Khatibi S, Johnston T, Pirro M, Sahebkar A . Curcumin as a MicroRNA Regulator in Cancer: A Review. Rev Physiol Biochem Pharmacol. 2016; 171:1-38. DOI: 10.1007/112_2016_3. View

10.

Standl E, Muller M, Schnell O . The impact of glucose-lowering therapy on cardiovascular outcomes. Best Pract Res Clin Endocrinol Metab. 2009; 23(3):401-11. DOI: 10.1016/j.beem.2009.03.010. View

11.

Sahebkar A, Henrotin Y . Analgesic Efficacy and Safety of Curcuminoids in Clinical Practice: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Pain Med. 2016; 17(6):1192-202. DOI: 10.1093/pm/pnv024. View

12.

Johansen J, Harris A, Rychly D, Ergul A . Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. Cardiovasc Diabetol. 2005; 4:5. PMC: 1131912. DOI: 10.1186/1475-2840-4-5. View

13.

Panahi Y, Hosseini M, Khalili N, Naimi E, Majeed M, Sahebkar A . Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis. Clin Nutr. 2015; 34(6):1101-8. DOI: 10.1016/j.clnu.2014.12.019. View

14.

Ghandadi M, Sahebkar A . Curcumin: An Effective Inhibitor of Interleukin-6. Curr Pharm Des. 2016; 23(6):921-931. DOI: 10.2174/1381612822666161006151605. View

15.

Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas P . Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998; 64(4):353-6. DOI: 10.1055/s-2006-957450. View

16.

Panahi Y, Khalili N, Hosseini M, Abbasinazari M, Sahebkar A . Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial. Complement Ther Med. 2014; 22(5):851-7. DOI: 10.1016/j.ctim.2014.07.006. View

17.

Miller N, Davies M, Gopinathan V, Milner A . A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin Sci (Lond). 1993; 84(4):407-12. DOI: 10.1042/cs0840407. View

18.

Panahi Y, Rahimnia A, Sharafi M, Alishiri G, Saburi A, Sahebkar A . Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial. Phytother Res. 2014; 28(11):1625-31. DOI: 10.1002/ptr.5174. View

19.

Esmaily H, Sahebkar A, Iranshahi M, Ganjali S, Mohammadi A, Ferns G . An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial. Chin J Integr Med. 2015; 21(5):332-8. DOI: 10.1007/s11655-015-2160-z. View

20.

Zabihi N, Pirro M, Johnston T, Sahebkar A . Is There a Role for Curcumin Supplementation in the Treatment of Non-Alcoholic Fatty Liver Disease? The Data Suggest Yes. Curr Pharm Des. 2016; 23(7):969-982. DOI: 10.2174/1381612822666161010115235. View