A New Agent in the Strategy to Cure AIDS

Overview

Journal Mol Ther

Publisher Cell Press

Specialties Molecular Biology
Pharmacology

Date 2016 Dec 6

PMID 27916996

Citations 1

Authors

John A Zaia

Affiliations

Soon will be listed here.

Citing Articles

David vs. Goliath: The Structure, Function, and Clinical Prospects of Antibody Fragments.

Bates A, Power C Antibodies (Basel). 2019; 8(2).

PMID: 31544834 PMC: 6640713. DOI: 10.3390/antib8020028.

References

Lum L, Thakur A . Targeting T cells with bispecific antibodies for cancer therapy. BioDrugs. 2011; 25(6):365-79. PMC: 3792709. DOI: 10.2165/11595950-000000000-00000. View

Yang H, Buisson S, Bossi G, Wallace Z, Hancock G, So C . Elimination of Latently HIV-infected Cells from Antiretroviral Therapy-suppressed Subjects by Engineered Immune-mobilizing T-cell Receptors. Mol Ther. 2016; 24(11):1913-1925. PMC: 5154472. DOI: 10.1038/mt.2016.114. View

Lederman M, Cannon P, Currier J, June C, Kiem H, Kuritzkes D . A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"?. Pathog Immun. 2016; 1(1):154-164. PMC: 5033048. DOI: 10.20411/pai.v1i1.133. View

Margolis D, Garcia J, Hazuda D, Haynes B . Latency reversal and viral clearance to cure HIV-1. Science. 2016; 353(6297):aaf6517. PMC: 5021637. DOI: 10.1126/science.aaf6517. View

Lederman M, Calabrese L, Funderburg N, Clagett B, Medvik K, Bonilla H . Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells. J Infect Dis. 2011; 204(8):1217-26. PMC: 3218674. DOI: 10.1093/infdis/jir507. View

Liddy N, Bossi G, Adams K, Lissina A, Mahon T, Hassan N . Monoclonal TCR-redirected tumor cell killing. Nat Med. 2012; 18(6):980-7. DOI: 10.1038/nm.2764. View

Fiorentini S, Marini E, Caracciolo S, Caruso A . Functions of the HIV-1 matrix protein p17. New Microbiol. 2006; 29(1):1-10. View

Loffler A, Kufer P, Lutterbuse R, Zettl F, Daniel P, Schwenkenbecher J . A recombinant bispecific single-chain antibody, CD19 x CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes. Blood. 2000; 95(6):2098-103. View

Grupp S, Kalos M, Barrett D, Aplenc R, Porter D, Rheingold S . Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med. 2013; 368(16):1509-1518. PMC: 4058440. DOI: 10.1056/NEJMoa1215134. View

10.

Staerz U, Bevan M . Hybrid hybridoma producing a bispecific monoclonal antibody that can focus effector T-cell activity. Proc Natl Acad Sci U S A. 1986; 83(5):1453-7. PMC: 323094. DOI: 10.1073/pnas.83.5.1453. View

11.

Deeks S, Lewin S, Ross A, Ananworanich J, Benkirane M, Cannon P . International AIDS Society global scientific strategy: towards an HIV cure 2016. Nat Med. 2016; 22(8):839-50. PMC: 5322797. DOI: 10.1038/nm.4108. View

12.

Day C, Kaufmann D, Kiepiela P, Brown J, Moodley E, Reddy S . PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature. 2006; 443(7109):350-4. DOI: 10.1038/nature05115. View

13.

Klinger M, Brandl C, Zugmaier G, Hijazi Y, Bargou R, Topp M . Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab. Blood. 2012; 119(26):6226-33. DOI: 10.1182/blood-2012-01-400515. View

14.

Bruner K, Murray A, Pollack R, Soliman M, Laskey S, Capoferri A . Defective proviruses rapidly accumulate during acute HIV-1 infection. Nat Med. 2016; 22(9):1043-9. PMC: 5014606. DOI: 10.1038/nm.4156. View

15.

Cabilly S, Riggs A, PANDE H, Shively J, Holmes W, Rey M . Generation of antibody activity from immunoglobulin polypeptide chains produced in Escherichia coli. Proc Natl Acad Sci U S A. 1984; 81(11):3273-7. PMC: 345489. DOI: 10.1073/pnas.81.11.3273. View

16.

Carvalho S, Levi-Schaffer F, Sela M, Yarden Y . Immunotherapy of cancer: from monoclonal to oligoclonal cocktails of anti-cancer antibodies: IUPHAR Review 18. Br J Pharmacol. 2016; 173(9):1407-24. PMC: 4831314. DOI: 10.1111/bph.13450. View

17.

Gill S, June C . Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies. Immunol Rev. 2014; 263(1):68-89. DOI: 10.1111/imr.12243. View

18.

Mack M, Riethmuller G, Kufer P . A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity. Proc Natl Acad Sci U S A. 1995; 92(15):7021-5. PMC: 41463. DOI: 10.1073/pnas.92.15.7021. View