Diabetic Wound Healing and Activation of Nrf2 by Herbal Medicine

Overview

Journal J Nat Sci

Date 2016 Nov 22

PMID 27868087

Citations 12

Authors

Donald R Senger

Shugeng Cao

Affiliations

Soon will be listed here.

Abstract

Nrf2 defense is a very important cellular mechanism to control oxidative stress, which is implicated in wound healing. Nrf2 can induce many cytoprotective genes, including HO-1, NQO1 and G6PD. Among many natural products that have been reported as Nrf2 activators, sulforaphane and curcumin have been studied more widely than any others, and both are in clinical trials for non-cancerous disorders. Recently, we reported 4-ethyl catechol and 4-vinyl catechol as Nrf2 co-factors that can induce Nrf2 as potently as sulforaphane and curcumin. These new Nrf2 co-factors were identified in hot aqueous extract of an herbal medicine , and fermented Noni () juice, which are used traditionally for diabetic wound healing.

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References

Holmstrom K, Baird L, Zhang Y, Hargreaves I, Chalasani A, Land J . Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration. Biol Open. 2013; 2(8):761-70. PMC: 3744067. DOI: 10.1242/bio.20134853. View

Hirota A, Kawachi Y, Yamamoto M, Koga T, Hamada K, Otsuka F . Acceleration of UVB-induced photoageing in nrf2 gene-deficient mice. Exp Dermatol. 2011; 20(8):664-8. DOI: 10.1111/j.1600-0625.2011.01292.x. View

Motohashi H, Yamamoto M . Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med. 2004; 10(11):549-57. DOI: 10.1016/j.molmed.2004.09.003. View

Abbott I, Shimazu C . The geographic origin of the plants most commonly used for medicine by Hawaiians. J Ethnopharmacol. 1985; 14(2-3):213-22. DOI: 10.1016/0378-8741(85)90089-3. View

Prochaska H, De Long M, Talalay P . On the mechanisms of induction of cancer-protective enzymes: a unifying proposal. Proc Natl Acad Sci U S A. 1985; 82(23):8232-6. PMC: 391477. DOI: 10.1073/pnas.82.23.8232. View

Yoh K, Itoh K, Enomoto A, Hirayama A, Yamaguchi N, Kobayashi M . Nrf2-deficient female mice develop lupus-like autoimmune nephritis. Kidney Int. 2001; 60(4):1343-53. DOI: 10.1046/j.1523-1755.2001.00939.x. View

Long M, Rojo de la Vega M, Wen Q, Bharara M, Jiang T, Zhang R . An Essential Role of NRF2 in Diabetic Wound Healing. Diabetes. 2016; 65(3):780-93. PMC: 4764153. DOI: 10.2337/db15-0564. View

Senger D, Hoang M, Kim K, Li C, Cao S . Anti-inflammatory activity of Barleria lupulina: Identification of active compounds that activate the Nrf2 cell defense pathway, organize cortical actin, reduce stress fibers, and improve cell junctions in microvascular endothelial cells. J Ethnopharmacol. 2016; 193:397-407. PMC: 5436582. DOI: 10.1016/j.jep.2016.09.017. View

Wruck C, Fragoulis A, Gurzynski A, Brandenburg L, Kan Y, Chan K . Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice. Ann Rheum Dis. 2010; 70(5):844-50. DOI: 10.1136/ard.2010.132720. View

10.

Holland R, Fishbein J . Chemistry of the cysteine sensors in Kelch-like ECH-associated protein 1. Antioxid Redox Signal. 2010; 13(11):1749-61. PMC: 2959180. DOI: 10.1089/ars.2010.3273. View

11.

Khor T, Huang M, Prawan A, Liu Y, Hao X, Yu S . Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer. Cancer Prev Res (Phila). 2009; 1(3):187-91. PMC: 3580177. DOI: 10.1158/1940-6207.CAPR-08-0028. View

12.

Itoh K, Mimura J, Yamamoto M . Discovery of the negative regulator of Nrf2, Keap1: a historical overview. Antioxid Redox Signal. 2010; 13(11):1665-78. DOI: 10.1089/ars.2010.3222. View

13.

Brown A . Anticancer activity of Morinda citrifolia (Noni) fruit: a review. Phytother Res. 2012; 26(10):1427-40. DOI: 10.1002/ptr.4595. View

14.

Fox R, Miller D, Phillips J, Hutchinson M, Havrdova E, Kita M . Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med. 2012; 367(12):1087-97. DOI: 10.1056/NEJMoa1206328. View

15.

Senger D, Li D, Jaminet S, Cao S . Activation of the Nrf2 Cell Defense Pathway by Ancient Foods: Disease Prevention by Important Molecules and Microbes Lost from the Modern Western Diet. PLoS One. 2016; 11(2):e0148042. PMC: 4757558. DOI: 10.1371/journal.pone.0148042. View

16.

Hayes J, Dinkova-Kostova A . The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem Sci. 2014; 39(4):199-218. DOI: 10.1016/j.tibs.2014.02.002. View

17.

Carroll R, Benya R, Turgeon D, Vareed S, Neuman M, Rodriguez L . Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. Cancer Prev Res (Phila). 2011; 4(3):354-64. PMC: 4136551. DOI: 10.1158/1940-6207.CAPR-10-0098. View

18.

Rao C, RIVENSON A, Simi B, Reddy B . Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res. 1995; 55(2):259-66. View

19.

Kensler T, Egner P, Agyeman A, Visvanathan K, Groopman J, Chen J . Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane. Top Curr Chem. 2012; 329:163-77. PMC: 3553557. DOI: 10.1007/128_2012_339. View

20.

Prasad S, Tyagi A, Aggarwal B . Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Cancer Res Treat. 2014; 46(1):2-18. PMC: 3918523. DOI: 10.4143/crt.2014.46.1.2. View