A Time Transect of Exomes from a Native American Population Before and After European Contact

Overview

Journal Nat Commun

Specialty Biology

Date 2016 Nov 16

PMID 27845766

Citations 60

Authors

John Lindo

Emilia Huerta-Sanchez

Shigeki Nakagome

Morten Rasmussen

Barbara Petzelt

Joycelynn Mitchell

Jerome S Cybulski

Eske Willerslev

Michael DeGiorgio

Ripan S Malhi

Affiliations

Soon will be listed here.

Abstract

A major factor for the population decline of Native Americans after European contact has been attributed to infectious disease susceptibility. To investigate whether a pre-existing genetic component contributed to this phenomenon, here we analyse 50 exomes of a continuous population from the Northwest Coast of North America, dating from before and after European contact. We model the population collapse after European contact, inferring a 57% reduction in effective population size. We also identify signatures of positive selection on immune-related genes in the ancient but not the modern group, with the strongest signal deriving from the human leucocyte antigen (HLA) gene HLA-DQA1. The modern individuals show a marked frequency decrease in the same alleles, likely due to the environmental change associated with European colonization, whereby negative selection may have acted on the same gene after contact. The evident shift in selection pressures correlates to the regional European-borne epidemics of the 1800s.

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