An Explanation of the Underlying Mechanisms for the In Vitro and In Vivo Antiurolithic Activity of

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2016 Nov 15

PMID 27840669

Citations 5

Authors

Qiang Liang

Xiaoran Li

Wangning Zhou

Yu Su

Shenbao He

Shuanglei Cheng

Jianzhong Lu

Wenjuan Cao

Yuke Yan

Xiaxia Pei

Jin Qi

Guangli Xu

Zhongjin Yue

Affiliations

Soon will be listed here.

Abstract

. To use in vitro and in vivo models to evaluate extract to provide scientific evidence for this extract's antiurolithic activity. . Potassium citrate was used as a positive control group. Oxidative stress (OS) markers and the expression of osteopontin (OPN) and kidney injury molecule-1 (KIM-1) were measured to assess the protective effects of . Multiple urolithiasis-related biochemical parameters were evaluated in urine and serum. Kidneys were harvested for histological examination and the assessment of crystal deposits. . In vitro and in vivo experiments demonstrated that treatment with extract significantly decreased calcium oxalate- (CaOx-) induced OPN expression, KIM-1 expression, and OS compared with the positive control group ( < 0.05). Additionally, in vivo rats that received extract exhibited significantly decreased CaOx deposits and pathological alterations ( < 0.05) compared with urolithic rats. Significantly lower levels of oxalate, creatinine, and urea and increased citrate levels were observed among rats that received ( < 0.05) compared with urolithic rats. . has antiurolithic effects due to its possible combined effects of increasing antioxidant levels, decreasing urinary stone-forming constituents and urolithiasis-related protein expression, and elevating urinary citrate levels.

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