Obesity, Type 2 Diabetes, and Impaired Insulin-stimulated Blood Flow: Role of Skeletal Muscle NO Synthase and Endothelin-1

Overview

Journal J Appl Physiol (1985)

Publisher American Physiological Society

Date 2016 Nov 1

PMID 27789766

Citations 39

Authors

Leryn J Reynolds

Daniel P Credeur

Camila Manrique

Jaume Padilla

Paul J Fadel

John P Thyfault

Affiliations

Soon will be listed here.

Abstract

New & Noteworthy: Although impairments in endothelial signaling are hypothesized to reduce insulin-stimulated blood flow in type 2 diabetes (T2D), human studies examining these links are limited. We provide the first measures of nitric oxide synthase and endothelin-1 expression from skeletal muscle tissue containing native microvessels in individuals with and without T2D before and during insulin stimulation. Higher basal skeletal muscle expression of endothelin-1 and reduced endothelial nitric oxide phosphorylation (peNOS)/eNOS may contribute to reduced insulin-stimulated blood flow in obese T2D patients.

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