Understanding Mouse Bile Acid Formation: Is It Time to Unwind Why Mice and Rats Make Unique Bile Acids?

Overview

Journal J Lipid Res

Publisher Elsevier

Specialty Biochemistry

Date 2016 Oct 26

PMID 27777318

Citations 15

Authors

Mats Rudling

Affiliations

Soon will be listed here.

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References

Makishima M, Okamoto A, REPA J, Tu H, Learned R, Luk A . Identification of a nuclear receptor for bile acids. Science. 1999; 284(5418):1362-5. DOI: 10.1126/science.284.5418.1362. View

Dueland S, Reichen J, Everson G, Davis R . Regulation of cholesterol and bile acid homoeostasis in bile-obstructed rats. Biochem J. 1991; 280 ( Pt 2):373-7. PMC: 1130556. DOI: 10.1042/bj2800373. View

Sayin S, Wahlstrom A, Felin J, Jantti S, Marschall H, Bamberg K . Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013; 17(2):225-35. DOI: 10.1016/j.cmet.2013.01.003. View

Kaur A, Patankar J, de Haan W, Ruddle P, Wijesekara N, Groen A . Loss of Cyp8b1 improves glucose homeostasis by increasing GLP-1. Diabetes. 2014; 64(4):1168-79. DOI: 10.2337/db14-0716. View

Hu X, Bonde Y, Eggertsen G, Rudling M . Muricholic bile acids are potent regulators of bile acid synthesis via a positive feedback mechanism. J Intern Med. 2013; 275(1):27-38. DOI: 10.1111/joim.12140. View

Zhang Y, Klaassen C . Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. J Lipid Res. 2010; 51(11):3230-42. PMC: 2952563. DOI: 10.1194/jlr.M007641. View

Murphy C, Parini P, Wang J, Bjorkhem I, Eggertsen G, Gafvels M . Cholic acid as key regulator of cholesterol synthesis, intestinal absorption and hepatic storage in mice. Biochim Biophys Acta. 2005; 1735(3):167-75. DOI: 10.1016/j.bbalip.2005.06.001. View

Parks D, Blanchard S, Bledsoe R, Chandra G, Consler T, Kliewer S . Bile acids: natural ligands for an orphan nuclear receptor. Science. 1999; 284(5418):1365-8. DOI: 10.1126/science.284.5418.1365. View

Gafvels M, Olin M, Lund E, Andersson U, Schuster G, Bjorkhem I . Cholic acid mediates negative feedback regulation of bile acid synthesis in mice. J Clin Invest. 2002; 110(8):1191-200. PMC: 150802. DOI: 10.1172/JCI16309. View

10.

Russell D . The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003; 72:137-74. DOI: 10.1146/annurev.biochem.72.121801.161712. View

11.

Bonde Y, Eggertsen G, Rudling M . Mice Abundant in Muricholic Bile Acids Show Resistance to Dietary Induced Steatosis, Weight Gain, and to Impaired Glucose Metabolism. PLoS One. 2016; 11(1):e0147772. PMC: 4732983. DOI: 10.1371/journal.pone.0147772. View

12.

Takahashi S, Fukami T, Masuo Y, Brocker C, Xie C, Krausz K . Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans. J Lipid Res. 2016; 57(12):2130-2137. PMC: 5321228. DOI: 10.1194/jlr.M071183. View

13.

Botham K, BOYD G . The metabolism of chenodeoxycholic acid to beta-muricholic acid in rat liver. Eur J Biochem. 1983; 134(1):191-6. DOI: 10.1111/j.1432-1033.1983.tb07550.x. View

14.

Wang D, Tazuma S, Cohen D, Carey M . Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse. Am J Physiol Gastrointest Liver Physiol. 2003; 285(3):G494-502. DOI: 10.1152/ajpgi.00156.2003. View

15.

Rabot S, Membrez M, Bruneau A, Gerard P, Harach T, Moser M . Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism. FASEB J. 2010; 24(12):4948-59. DOI: 10.1096/fj.10-164921. View

16.

Howard W, Pospisil J, Njolito E, Noonan D . Catabolites of cholesterol synthesis pathways and forskolin as activators of the farnesoid X-activated nuclear receptor. Toxicol Appl Pharmacol. 2000; 163(2):195-202. DOI: 10.1006/taap.1999.8869. View