Design of HIFU Transducers for Generating Specified Nonlinear Ultrasound Fields

Overview

Journal IEEE Trans Ultrason Ferroelectr Freq Control

Specialties Biomedical Engineering
Nuclear Medicine

Date 2016 Oct 25

PMID 27775904

Citations 36

Authors

Pavel B Rosnitskiy

Petr V Yuldashev

Oleg A Sapozhnikov

Adam D Maxwell

Wayne Kreider

Michael R Bailey

Vera A Khokhlova

Affiliations

Soon will be listed here.

Abstract

Various clinical applications of high-intensity focused ultrasound have different requirements for the pressure levels and degree of nonlinear waveform distortion at the focus. The goal of this paper is to determine transducer design parameters that produce either a specified shock amplitude in the focal waveform or specified peak pressures while still maintaining quasi-linear conditions at the focus. Multiparametric nonlinear modeling based on the Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation with an equivalent source boundary condition was employed. Peak pressures, shock amplitudes at the focus, and corresponding source outputs were determined for different transducer geometries and levels of nonlinear distortion. The results are presented in terms of the parameters of an equivalent single-element spherically shaped transducer. The accuracy of the method and its applicability to cases of strongly focused transducers were validated by comparing the KZK modeling data with measurements and nonlinear full diffraction simulations for a single-element source and arrays with 7 and 256 elements. The results provide look-up data for evaluating nonlinear distortions at the focus of existing therapeutic systems as well as for guiding the design of new transducers that generate specified nonlinear fields.

Citing Articles

Histotripsy-Induced Bactericidal Activity Correlates to Size of Cavitation Cloud In Vitro.

Ambekar P, Wang Y, Khokhlova T, Khokhlova T, Thomas G, Thomas G IEEE Trans Ultrason Ferroelectr Freq Control. 2024; 71:1868-1878.

PMID: 39383065 PMC: 11875908. DOI: 10.1109/TUFFC.2024.3476438.

Histotripsy: A Method for Mechanical Tissue Ablation with Ultrasound.

Xu Z, Khokhlova T, Cho C, Khokhlova V Annu Rev Biomed Eng. 2024; 26(1):141-167.

PMID: 38346277 PMC: 11837764. DOI: 10.1146/annurev-bioeng-073123-022334.

Treatment Planning and Aberration Correction Algorithm for HIFU Ablation of Renal Tumors.

Rosnitskiy P, Khokhlova T, Schade G, Sapozhnikov O, Khokhlova V IEEE Trans Ultrason Ferroelectr Freq Control. 2024; 71(3):341-353.

PMID: 38231825 PMC: 11003458. DOI: 10.1109/TUFFC.2024.3355390.

Self-enhancing sono-inks enable deep-penetration acoustic volumetric printing.

Kuang X, Rong Q, Belal S, Vu T, Lopez Lopez A, Wang N Science. 2023; 382(6675):1148-1155.

PMID: 38060634 PMC: 11034850. DOI: 10.1126/science.adi1563.

Comparative Study of Histotripsy Pulse Parameters Used to Inactivate Escherichia coli in Suspension.

Ambekar P, Wang Y, Khokhlova T, Bruce M, Leotta D, Totten S Ultrasound Med Biol. 2023; 49(12):2451-2458.

PMID: 37718123 PMC: 10591824. DOI: 10.1016/j.ultrasmedbio.2023.08.004.

References

Khokhlova T, Canney M, Khokhlova V, Sapozhnikov O, Crum L, Bailey M . Controlled tissue emulsification produced by high intensity focused ultrasound shock waves and millisecond boiling. J Acoust Soc Am. 2011; 130(5):3498-510. PMC: 3259668. DOI: 10.1121/1.3626152. View

Cranston D . A review of high intensity focused ultrasound in relation to the treatment of renal tumours and other malignancies. Ultrason Sonochem. 2015; 27:654-658. DOI: 10.1016/j.ultsonch.2015.05.035. View

Tavakkoli J, Cathignol D, Souchon R, Sapozhnikov O . Modeling of pulsed finite-amplitude focused sound beams in time domain. J Acoust Soc Am. 1999; 104(4):2061-72. DOI: 10.1121/1.423720. View

Kreider W, Yuldashev P, Sapozhnikov O, Farr N, Partanen A, Bailey M . Characterization of a multi-element clinical HIFU system using acoustic holography and nonlinear modeling. IEEE Trans Ultrason Ferroelectr Freq Control. 2014; 60(8):1683-98. PMC: 4130294. DOI: 10.1109/TUFFC.2013.2750. View

Pahk K, Mohammad G, Malago M, Saffari N, Dhar D . A Novel Approach to Ultrasound-Mediated Tissue Decellularization and Intra-Hepatic Cell Delivery in Rats. Ultrasound Med Biol. 2016; 42(8):1958-67. DOI: 10.1016/j.ultrasmedbio.2016.03.020. View

Huijssen J, Verweij M . An iterative method for the computation of nonlinear, wide-angle, pulsed acoustic fields of medical diagnostic transducers. J Acoust Soc Am. 2010; 127(1):33-44. DOI: 10.1121/1.3268599. View

Elias W, Huss D, Voss T, Loomba J, Khaled M, Zadicario E . A pilot study of focused ultrasound thalamotomy for essential tremor. N Engl J Med. 2013; 369(7):640-8. DOI: 10.1056/NEJMoa1300962. View

Hoogenboom M, Eikelenboom D, den Brok M, Heerschap A, Futterer J, Adema G . Mechanical high-intensity focused ultrasound destruction of soft tissue: working mechanisms and physiologic effects. Ultrasound Med Biol. 2015; 41(6):1500-17. DOI: 10.1016/j.ultrasmedbio.2015.02.006. View

Crouzet S, Chapelon J, Rouviere O, Mege-Lechevallier F, Colombel M, Tonoli-Catez H . Whole-gland ablation of localized prostate cancer with high-intensity focused ultrasound: oncologic outcomes and morbidity in 1002 patients. Eur Urol. 2013; 65(5):907-14. DOI: 10.1016/j.eururo.2013.04.039. View

10.

Fry F, Sanghvi N, Foster R, Bihrle R, Hennige C . Ultrasound and microbubbles: their generation, detection and potential utilization in tissue and organ therapy--experimental. Ultrasound Med Biol. 1995; 21(9):1227-37. DOI: 10.1016/0301-5629(96)89519-6. View

11.

Yuldashev P, Khokhlova V . SIMULATION OF THREE-DIMENSIONAL NONLINEAR FIELDS OF ULTRASOUND THERAPEUTIC ARRAYS. Acoust Phys. 2011; 57(3):334-343. PMC: 3145364. DOI: 10.1134/S1063771011030213. View

12.

Lin K, Kim Y, Maxwell A, Wang T, Hall T, Xu Z . Histotripsy beyond the intrinsic cavitation threshold using very short ultrasound pulses: microtripsy. IEEE Trans Ultrason Ferroelectr Freq Control. 2014; 61(2):251-65. PMC: 3966303. DOI: 10.1109/TUFFC.2014.6722611. View

13.

Martin E, Ling Y, Treeby B . Simulating Focused Ultrasound Transducers Using Discrete Sources on Regular Cartesian Grids. IEEE Trans Ultrason Ferroelectr Freq Control. 2016; 63(10):1535-1542. DOI: 10.1109/TUFFC.2016.2600862. View

14.

Zemp R, Tavakkoli J, Cobbold R . Modeling of nonlinear ultrasound propagation in tissue from array transducers. J Acoust Soc Am. 2003; 113(1):139-52. DOI: 10.1121/1.1528926. View

15.

Bessonova O, Wilkens V . Membrane hydrophone measurement and numerical simulation of HIFU fields up to developed shock regimes. IEEE Trans Ultrason Ferroelectr Freq Control. 2013; 60(2):290-300. DOI: 10.1109/TUFFC.2013.2565. View

16.

Vaezy S, Shi X, Martin R, Chi E, Nelson P, Bailey M . Real-time visualization of high-intensity focused ultrasound treatment using ultrasound imaging. Ultrasound Med Biol. 2001; 27(1):33-42. DOI: 10.1016/s0301-5629(00)00279-9. View

17.

Canney M, Bailey M, Crum L, Khokhlova V, Sapozhnikov O . Acoustic characterization of high intensity focused ultrasound fields: a combined measurement and modeling approach. J Acoust Soc Am. 2008; 124(4):2406-20. PMC: 2677345. DOI: 10.1121/1.2967836. View

18.

Averiyanov M, Ollivier S, Khokhlova V, Blanc-Benon P . Random focusing of nonlinear acoustic N-waves in fully developed turbulence: laboratory scale experiment. J Acoust Soc Am. 2012; 130(6):3595-607. DOI: 10.1121/1.3652869. View

19.

Dubinsky T, Cuevas C, Dighe M, Kolokythas O, Hwang J . High-intensity focused ultrasound: current potential and oncologic applications. AJR Am J Roentgenol. 2007; 190(1):191-9. DOI: 10.2214/AJR.07.2671. View

20.

Varslot T, Taraldsen G . Computer simulation of forward wave propagation in soft tissue. IEEE Trans Ultrason Ferroelectr Freq Control. 2005; 52(9):1473-82. DOI: 10.1109/tuffc.2005.1516019. View