The Effects of Nifedipine on Respiratory Mechanics Investigated by Theend-inflation Occlusion Method in the Rat

Overview

Journal J Enzyme Inhib Med Chem

Specialty Biochemistry

Date 2016 Oct 22

PMID 27766901

Citations 2

Authors

Alessandro Rubini

Vincenzo Catena

Daniele Del Monte

Gerardo Bosco

Affiliations

Soon will be listed here.

Abstract

Context: Calcium channel blockers may theoretically exhibit relaxing effects not only on vascular smooth muscle but also on airway smooth muscle.

Objective: To investigate possible effects of nifedipine on respiratory mechanics in the rat.

Methods: Respiratory system mechanical parameters were measured by the end-inflation occlusion method in the rat in vivo before and after the intraperitoneal administration of nifedipine.

Results: We found that nifedipine affects respiratory mechanics, inducing a reduction of airway resistance and of respiratory system elastance, probably because of a relaxing action on airway and parenchimal smooth muscle cells.

Conclusion: Should these results be further confirmed by human investigations, a possible role of nifedipine in pharmacological respiratory system's diseases treatment may be suggested.

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