Effects of Propofol on Respiratory Mechanic and Lung Histology in Normal Rats

Overview

Journal Br J Anaesth

Publisher Elsevier

Specialty Anesthesiology

Date 2004 Mar 23

PMID 15033891

Citations 10

Authors

A Peratoner

C S Nascimento

M C E Santana

R A Cadete

E M Negri

A Gullo

P R M Rocco

W A Zin

Affiliations

Soon will be listed here.

Abstract

Background: Propofol is able to reduce airway resistance in lungs with previous airway constriction. The aim of this study was to evaluate the effects of propofol on respiratory mechanics in normal rats and to correlate these parameters with lung histology, to define the sites of action of propofol.

Methods: Sixteen Wistar rats were divided into two groups of eight animals. Rats were sedated (diazepam) and anaesthetized with pentobarbital sodium (C) or propofol (P), and paralysed. Respiratory system, lung, and chest wall resistive, elastic, and viscoelastic/inhomogeneous pressures were computed using the end-inflation occlusion method.

Results: Lung resistive pressure was smaller in group P (0.29 kPa (0.05)) than group C (0.37 kPa (0.04)) (P=0.007). The internal diameter of the central airways was greater in group P than C (P=0.01).

Conclusion: Propofol acts at the airway level decreasing respiratory system and lung impedances as a result of central airway dilation.

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