Human Adipose-derived Mesenchymal Stem Cell Spheroids Improve Recovery in a Mouse Model of Elastase-induced Emphysema

Overview

Journal BMB Rep

Specialties Biochemistry
Molecular Biology

Date 2016 Oct 21

PMID 27756443

Citations 21

Authors

Ryeon Jin Cho

You-Sun Kim

Ji-Young Kim

Yeon-Mok Oh

Affiliations

Soon will be listed here.

Abstract

Emphysema, a pathologic component of the chronic obstructive pulmonary disease, causes irreversible destruction of lung. Many researchers have reported that mesenchymal stem cells can regenerate lung tissue after emphysema. We evaluated if spheroid human adipose-derived mesenchymal stem cells (ASCs) showed greater regenerative effects than dissociated ASCs in mice with elastase-induced emphysema. ASCs were administered via an intrapleural route. Mice injected with spheroid ASCs showed improved regeneration of lung tissues, increased expression of growth factors such as fibroblast growth factor-2 (FGF2) and hepatocyte growth factor (HGF), and a reduction in proteases with an induction of protease inhibitors when compared with mice injected with dissociated ASCs. Our findings indicate that spheroid ASCs show better regeneration of lung tissues than dissociated ACSs in mice with elastase-induced emphysema. [BMB Reports 2017; 50(2): 79-84].

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