Adipose Tissue-Derived Stem Cells Have the Ability to Differentiate into Alveolar Epithelial Cells and Ameliorate Lung Injury Caused by Elastase-Induced Emphysema in Mice

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2019 Jul 9

PMID 31281377

Citations 9

Authors

Eriko Fukui

Soichiro Funaki

Kenji Kimura

Toru Momozane

Atsuomi Kimura

Ryota Chijimatsu

Ryu Kanzaki

Takashi Kanou

Naoko Ose

Masato Minami

Shigeru Miyagawa

Yoshiki Sawa

Meinoshin Okumura

Yasushi Shintani

Affiliations

Soon will be listed here.

Abstract

Chronic obstructive pulmonary disease is a leading cause of mortality globally, with no effective therapy yet established. Adipose tissue-derived stem cells (ADSCs) are useful for ameliorating lung injury in animal models. However, whether ADSCs differentiate into functional cells remains uncertain, and no study has reported on the mechanism by which ADSCs improve lung functionality. Thus, in this study, we examined whether ADSCs differentiate into lung alveolar cells and are able to ameliorate lung injury caused by elastase-induced emphysema in model mice. Here, we induced ADSCs to differentiate into type 2 alveolar epithelial cells in vitro. We demonstrated that ADSCs can differentiate into type 2 alveolar epithelial cells in an elastase-induced emphysematous lung and that ADSCs improve pulmonary function of emphysema model mice, as determined with spirometry and Xe MRI. These data revealed a novel function for ADSCs in promoting repair of the damaged lung by direct differentiation into alveolar epithelial cells.

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