Extract Improves Insulin Sensitivity and Suppresses Hepatic Gluconeogenesis in C57BL/KsJ- Mice

Overview

Journal Nutr Res Pract

Specialty Nutritional Sciences

Date 2016 Oct 5

PMID 27698958

Citations 4

Authors

Sung-In Choi

Hyun-Ah Lee

Ji-Sook Han

Affiliations

Soon will be listed here.

Abstract

Background/objectives: This study was designed to investigate whether extract (GPE) can improve insulin sensitivity and suppress hepatic glucose production in an animal model of type 2 diabetes.

Materials/methods: C57BL/Ksj-db/db mice were divided into 3 groups, a regular diet (control), GPE, and rosiglitazone groups (0.005 g/100 g diet) and fed for 6 weeks.

Results: Mice supplemented with GPE showed significantly lower blood levels of glucose and glycosylated hemoglobin than diabetic control mice. Glucose and insulin tolerance test also showed the positive effect of GPE on increasing insulin sensitivity. The homeostatic index of insulin resistance was significantly lower in mice supplemented with GPE than in the diabetic control mice. In the skeletal muscle, the expression of phosphorylated AMP-activated protein kinase, pAkt substrate of 160 kDa, and PM-glucose transporter type 4 increased in mice supplemented with GPE when compared to that of the diabetic control mice. GPE also decreased the expression of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase in the liver.

Conclusions: These findings demonstrate that GPE might improve insulin sensitivity and inhibit gluconeogenesis in the liver.

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Retraction: extract improves insulin sensitivity and suppresses hepatic gluconeogenesis in C57BL/KsJ- mice.

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