Maternal Diet During Pregnancy and Micronuclei Frequency in Peripheral Blood T Lymphocytes in Mothers and Newborns (Rhea Cohort, Crete)

Overview

Journal Eur J Nutr

Specialty Nutritional Sciences

Date 2016 Sep 23

PMID 27655526

Citations 5

Authors

Cristina OCallaghan-Gordo

Manolis Kogevinas

Marie Pedersen

Eleni Fthenou

Ana Espinosa

Xristina Tsiapa

Georgia Chalkiadaki

Vasiliki Daraki

Eirini Dermitzaki

Ilse Decordier

Peter B Farmer

Panagiotis Georgiadis

Vaggelis Georgiou

Soterios A Kyrtopoulos

Domenico Franco Merlo

Dora Romaguera

Theano Roumeliotaki

Katerina Sarri

Margareta Tornqvist

Kim Vande Loock

Hans von Stedingk

Jos Kleinjans

Micheline Kirsch-Volders

Leda Chatzi

Affiliations

Soon will be listed here.

Abstract

Purpose: The study assessed whether diet and adherence to cancer prevention guidelines during pregnancy were associated with micronucleus (MN) frequency in mothers and newborns. MN is biomarkers of early genetic effects that have been associated with cancer risk in adults.

Methods: A total of 188 mothers and 200 newborns from the Rhea cohort (Greece) were included in the study. At early-mid pregnancy, we conducted personal interviews and a validated food frequency questionnaire was completed. With this information, we constructed a score reflecting adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention guidelines on diet, physical activity and body fatness. At delivery, maternal and/or cord blood was collected to measure DNA and hemoglobin adducts of dietary origin and frequencies of MN in binucleated and mononucleated T lymphocytes (MNBN and MNMONO).

Results: In mothers, higher levels of red meat consumption were associated with increased MNBN frequency [2nd tertile IRR = 1.34 (1.00, 1.80), 3rd tertile IRR = 1.33 (0.96, 1.85)] and MNMONO frequency [2nd tertile IRR = 1.53 (0.84, 2.77), 3rd tertile IRR = 2.69 (1.44, 5.05)]. The opposite trend was observed for MNBN in newborns [2nd tertile IRR = 0.64 (0.44, 0.94), 3rd tertile IRR = 0.68 (0.46, 1.01)], and no association was observed with MNMONO. Increased MN frequency in pregnant women with high red meat consumption is consistent with previous knowledge.

Conclusions: Our results also suggest exposure to genotoxics during pregnancy might affect differently mothers and newborns. The predictive value of MN as biomarker for childhood cancer, rather than adulthood, remains unclear. With few exceptions, the association between maternal carcinogenic exposures during pregnancy and childhood cancer or early biologic effect biomarkers remains poorly understood.

Citing Articles

Effect of maternal diet on the frequency of micronuclei in pregnant women and newborns: A protocol for systematic review and meta-analysis.

Araujo A, Medeiros M, do Nascimento P, Cobucci R, Bortolin R, Rezende A PLoS One. 2024; 19(3):e0300714.

PMID: 38527051 PMC: 10962814. DOI: 10.1371/journal.pone.0300714.

Joint associations among prenatal metal mixtures and nutritional factors on birth weight z-score: Evidence from an urban U.S. population.

Zhang X, Chiu Y, Kannan S, Cowell W, Deng W, Coull B Environ Res. 2022; 208:112675.

PMID: 34995543 PMC: 8916990. DOI: 10.1016/j.envres.2022.112675.

The Effect of Pregnancy in the Hemoglobin Concentration of Pregnant Women: A Longitudinal Study.

Feleke B, Feleke T J Pregnancy. 2020; 2020:2789536.

PMID: 32566297 PMC: 7290874. DOI: 10.1155/2020/2789536.

The Impact of Mother's Living Environment Exposure on Genome Damage, Immunological Status, and Sex Hormone Levels in Newborns.

Fucic A, Starcevic M, Sindicic Dessardo N, Batinic D, Kralik S, Krasic J Int J Environ Res Public Health. 2020; 17(10).

PMID: 32414150 PMC: 7277460. DOI: 10.3390/ijerph17103402.

Diet in pregnancy-more than food.

Danielewicz H, Myszczyszyn G, Debinska A, Myszkal A, Boznanski A, Hirnle L Eur J Pediatr. 2017; 176(12):1573-1579.

PMID: 29101450 PMC: 5682869. DOI: 10.1007/s00431-017-3026-5.

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