Vitamin D Deficiency Is Associated with Severity of Acute Coronary Syndrome in Patients with Type 2 Diabetes and High Rates of Sun Exposure

Overview

Journal Clin Med Insights Endocrinol Diabetes

Publisher Sage Publications

Specialty Endocrinology

Date 2016 Sep 15

PMID 27625577

Citations 7

Authors

Fernando Gondim

Ana Caribe

Karine Ferreira Vasconcelos

Alexandre Dantas Segundo

Francisco Bandeira

Affiliations

Soon will be listed here.

Abstract

Background: Vitamin D deficiency has been associated with cardiovascular risk factors, including type 2 diabetes mellitus (T2DM). Evidence shows that patients with low serum 25-hydroxyvitamin D (25OHD) concentrations have a higher risk of developing coronary artery disease.

Objective: The objective of this study was to assess vitamin D as a predictor of the severity in diabetics with acute coronary syndrome (ACS).

Methods: A total of 166 patients were diagnosed with ACS. Serum 25OHD concentrations were analyzed, and risk factors for ACS were evaluated.

Results: Patients diagnosed as having acute myocardial infarction with elevation of the ST segment had a higher rate of 25OHD, <20 ng/mL compared to ≥30 ng/mL (47.8% × 13.4%, P = 0.03). Diabetics with vitamin D deficiency had more multivessel lesions in the coronary angiography than non-diabetics (69% × 31.8%, P = 0.007). After adjustments for confounders, serum 25OHD remained associated with more severe disease.

Conclusion: Vitamin D deficiency is associated with more severe ACS and is a predictor of more extensive coronary lesions in patients with T2DM.

Citing Articles

Associations between vitamin D status, gene polymorphisms and echocardiographic markers in Polish patients with cardiovascular disease.

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Vitamin D: Not Just Bone Metabolism but a Key Player in Cardiovascular Diseases.

Izzo M, Carrizzo A, Izzo C, Cappello E, Cecere D, Ciccarelli M Life (Basel). 2021; 11(5).

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Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007-2017.

Einarson T, Acs A, Ludwig C, Panton U Cardiovasc Diabetol. 2018; 17(1):83.

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Association of Vitamin D Deficiency and Degree of Coronary Artery Disease in Cardiac Patients with Type 2 Diabetes.

Dziedzic E, Gasior J, Pawlowski M, Dabrowski M J Diabetes Res. 2017; 2017:3929075.

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The association of serum vitamin D concentration and ventricular dysfunction among patients with acute coronary syndrome.

Khademvatani K, Mohammadzad M, Yekta Z, Hadizadeh O Ther Clin Risk Manag. 2017; 13:1455-1461.

PMID: 29118583 PMC: 5659220. DOI: 10.2147/TCRM.S144437.

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