Effect of Serum 25-hydroxyvitamin D on Risk for Type 2 Diabetes May Be Partially Mediated by Subclinical Inflammation: Results from the MONICA/KORA Augsburg Study

Overview

Journal Diabetes Care

Specialty Endocrinology

Date 2011 Aug 30

PMID 21873558

Citations 35

Authors

Barbara Thorand

Astrid Zierer

Cornelia Huth

Jakob Linseisen

Christa Meisinger

Michael Roden

Annette Peters

Wolfgang Koenig

Christian Herder

Affiliations

Soon will be listed here.

Abstract

Objective: To assess the association between serum 25-hydroxyvitamin D (25-OHD) and incident type 2 diabetes and to determine whether the association is mediated by subclinical inflammation.

Research Design And Methods: Using a case-cohort design, baseline levels of 25-OHD were measured in 416 case subjects with incident type 2 diabetes and 1,267 noncase subjects selected from a source population of 7,936 middle-aged participants in the population-based Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA)/Cooperative Health Research in the Region of Augsburg (KORA) study.

Results: A significant inverse association was observed between serum 25-OHD and incident type 2 diabetes after adjustment for diabetes risk factors and season. The hazard ratio (HR) and 95% CI comparing tertile extremes was 0.63 (0.44-0.90) (P(trend) = 0.010). Further adjustment for C-reactive protein, interleukin-6, soluble intercellular adhesion molecule-1, and interferon-γ-inducible protein-10 attenuated this association by 16% (HR 0.73 [0.50-1.05], P = 0.090).

Conclusions: Vitamin D status is inversely related to type 2 diabetes risk and our data suggest that this association may be partially mediated by subclinical inflammation.

Citing Articles

Vitamin D and Risk of Incident Type 2 Diabetes in Older Adults: An Updated Systematic Review and Meta-Analysis.

Dominguez L, Veronese N, Marrone E, Di Palermo C, Iommi C, Ruggirello R Nutrients. 2024; 16(11).

PMID: 38892495 PMC: 11173817. DOI: 10.3390/nu16111561.

Immune Response in Vitamin D Deficient Metastatic Colorectal Cancer Patients: A Player That Should Be Considered for Targeted Vitamin D Supplementation.

Morelli C, Rofei M, Riondino S, Fraboni D, Torino F, Orlandi A Cancers (Basel). 2022; 14(11).

PMID: 35681576 PMC: 9179512. DOI: 10.3390/cancers14112594.

Biomarker-defined pathways for incident type 2 diabetes and coronary heart disease-a comparison in the MONICA/KORA study.

Huth C, Bauer A, Zierer A, Sudduth-Klinger J, Meisinger C, Roden M Cardiovasc Diabetol. 2020; 19(1):32.

PMID: 32164753 PMC: 7066738. DOI: 10.1186/s12933-020-01003-w.

Low Serum Vitamin D Concentrations Are Associated with Insulin Resistance in Mexican Children and Adolescents.

Denova-Gutierrez E, Munoz-Aguirre P, Lopez D, Flores M, Medeiros M, Tamborrel N Nutrients. 2019; 11(9).

PMID: 31491877 PMC: 6770751. DOI: 10.3390/nu11092109.

Interaction Between Vitamin D and Interleukin 6 on Slow Gait Speed: 6-Year Follow-up Data of Older Adults From InCHIANTI.

Kositsawat J, Kuo C, Barry L, Melzer D, Bandinelli S, Ferrucci L J Gerontol A Biol Sci Med Sci. 2019; 75(6):1161-1166.

PMID: 31282535 PMC: 7243581. DOI: 10.1093/gerona/glz165.

References

Thorand B, Baumert J, Kolb H, Meisinger C, Chambless L, Koenig W . Sex differences in the prediction of type 2 diabetes by inflammatory markers: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. Diabetes Care. 2007; 30(4):854-60. DOI: 10.2337/dc06-1693. View

Knekt P, Laaksonen M, Mattila C, Harkanen T, Marniemi J, Heliovaara M . Serum vitamin D and subsequent occurrence of type 2 diabetes. Epidemiology. 2008; 19(5):666-71. DOI: 10.1097/EDE.0b013e318176b8ad. View

Mattila C, Knekt P, Mannisto S, Rissanen H, Laaksonen M, Montonen J . Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes. Diabetes Care. 2007; 30(10):2569-70. DOI: 10.2337/dc07-0292. View

Holick M . Vitamin D deficiency. N Engl J Med. 2007; 357(3):266-81. DOI: 10.1056/NEJMra070553. View

Gagnon C, Lu Z, Magliano D, Dunstan D, Shaw J, Zimmet P . Serum 25-hydroxyvitamin D, calcium intake, and risk of type 2 diabetes after 5 years: results from a national, population-based prospective study (the Australian Diabetes, Obesity and Lifestyle study). Diabetes Care. 2011; 34(5):1133-8. PMC: 3114481. DOI: 10.2337/dc10-2167. View

Forouhi N, Luan J, Cooper A, Boucher B, Wareham N . Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes. 2008; 57(10):2619-25. PMC: 2551670. DOI: 10.2337/db08-0593. View

Robinson J, Manson J, Larson J, Liu S, Song Y, Howard B . Lack of association between 25(OH)D levels and incident type 2 diabetes in older women. Diabetes Care. 2011; 34(3):628-34. PMC: 3041195. DOI: 10.2337/dc10-1632. View

Pittas A, Sun Q, Manson J, Dawson-Hughes B, Hu F . Plasma 25-hydroxyvitamin D concentration and risk of incident type 2 diabetes in women. Diabetes Care. 2010; 33(9):2021-3. PMC: 2928356. DOI: 10.2337/dc10-0790. View

Thorand B, Kolb H, Baumert J, Koenig W, Chambless L, Meisinger C . Elevated levels of interleukin-18 predict the development of type 2 diabetes: results from the MONICA/KORA Augsburg Study, 1984-2002. Diabetes. 2005; 54(10):2932-8. DOI: 10.2337/diabetes.54.10.2932. View

10.

Grimnes G, Emaus N, Joakimsen R, Figenschau Y, Jenssen T, Njolstad I . Baseline serum 25-hydroxyvitamin D concentrations in the Tromsø Study 1994-95 and risk of developing type 2 diabetes mellitus during 11 years of follow-up. Diabet Med. 2010; 27(10):1107-15. DOI: 10.1111/j.1464-5491.2010.03092.x. View

11.

Herder C, Baumert J, Zierer A, Roden M, Meisinger C, Karakas M . Immunological and cardiometabolic risk factors in the prediction of type 2 diabetes and coronary events: MONICA/KORA Augsburg case-cohort study. PLoS One. 2011; 6(6):e19852. PMC: 3108947. DOI: 10.1371/journal.pone.0019852. View

12.

Kolb H, Mandrup-Poulsen T . An immune origin of type 2 diabetes?. Diabetologia. 2005; 48(6):1038-50. DOI: 10.1007/s00125-005-1764-9. View

13.

Barlow W . Robust variance estimation for the case-cohort design. Biometrics. 1994; 50(4):1064-72. View