The Role of Toll-Like Receptors and Vitamin D in Cardiovascular Diseases-A Review

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2017 Oct 28

PMID 29077004

Citations 15

Authors

Daria M Adamczak

Affiliations

Soon will be listed here.

Abstract

Cardiovascular diseases are the leading cause of mortality worldwide. Therefore, a better understanding of their pathomechanisms and the subsequent implementation of optimal prophylactic and therapeutic strategies are of utmost importance. A growing body of evidence states that low-grade inflammation is a common feature for most of the cardiovascular diseases in which the contributing factors are the activation of toll-like receptors (TLRs) and vitamin D deficiency. In this article, available data concerning the association of cardiovascular diseases with TLRs and vitamin D status are reviewed, followed by a discussion of new possible approaches to cardiovascular disease management.

Citing Articles

The Role of TLRs in Obesity and Its Related Metabolic Disorders.

Campos-Bayardo T, Roman-Rojas D, Garcia-Sanchez A, Cardona-Munoz E, Sanchez-Lozano D, Totsuka-Sutto S Int J Mol Sci. 2025; 26(5).

PMID: 40076851 PMC: 11900219. DOI: 10.3390/ijms26052229.

Unveiling the Interplay-Vitamin D and ACE-2 Molecular Interactions in Mitigating Complications and Deaths from SARS-CoV-2.

Wimalawansa S Biology (Basel). 2024; 13(10).

PMID: 39452140 PMC: 11504239. DOI: 10.3390/biology13100831.

Physiology of Vitamin D-Focusing on Disease Prevention.

Wimalawansa S Nutrients. 2024; 16(11).

PMID: 38892599 PMC: 11174958. DOI: 10.3390/nu16111666.

Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo.

Nilsen K, Zhang B, Skjesol A, Ryan L, Vagle H, Boe M Life Sci Alliance. 2023; 6(12).

PMID: 37788908 PMC: 10547912. DOI: 10.26508/lsa.202302164.

Lung Inflammation Induced by Inactivated SARS-CoV-2 in C57BL/6 Female Mice Is Controlled by Intranasal Instillation of Vitamin D.

Fernandes de Souza W, Zorzella-Pezavento S, Ayupe M, Salgado C, Oliveira B, Moreira F Cells. 2023; 12(7).

PMID: 37048165 PMC: 10093523. DOI: 10.3390/cells12071092.

References

Gouni-Berthold I, Krone W, Berthold H . Vitamin D and cardiovascular disease. Curr Vasc Pharmacol. 2009; 7(3):414-22. DOI: 10.2174/157016109788340686. View

Stevens S, Ciesielski T, Marsh B, Yang T, Homen D, Boule J . Toll-like receptor 9: a new target of ischemic preconditioning in the brain. J Cereb Blood Flow Metab. 2008; 28(5):1040-7. PMC: 3037270. DOI: 10.1038/sj.jcbfm.9600606. View

Toli K, Paraskevas K, Poulakou M, Agrogiannis G, Kavantzas N, Xanthopoulos V . Association between plasma levels and immunolocalization of cytokines in heart valve lesions: a possible target for treatment?. Expert Opin Ther Targets. 2008; 12(10):1209-15. DOI: 10.1517/14728222.12.10.1209. View

Goulopoulou S, McCarthy C, Webb R . Toll-like Receptors in the Vascular System: Sensing the Dangers Within. Pharmacol Rev. 2016; 68(1):142-67. PMC: 4709508. DOI: 10.1124/pr.114.010090. View

Shea M, ODonnell C, Hoffmann U, Dallal G, Dawson-Hughes B, Ordovas J . Vitamin K supplementation and progression of coronary artery calcium in older men and women. Am J Clin Nutr. 2009; 89(6):1799-807. PMC: 2682995. DOI: 10.3945/ajcn.2008.27338. View

Brea D, Sobrino T, Rodriguez-Yanez M, Ramos-Cabrer P, Agulla J, Rodriguez-Gonzalez R . Toll-like receptors 7 and 8 expression is associated with poor outcome and greater inflammatory response in acute ischemic stroke. Clin Immunol. 2011; 139(2):193-8. DOI: 10.1016/j.clim.2011.02.001. View

Knuefermann P, Sakata Y, Scott Baker J, Huang C, Sekiguchi K, Hardarson H . Toll-like receptor 2 mediates Staphylococcus aureus-induced myocardial dysfunction and cytokine production in the heart. Circulation. 2004; 110(24):3693-8. DOI: 10.1161/01.CIR.0000143081.13042.04. View

Holick M . Vitamin D deficiency. N Engl J Med. 2007; 357(3):266-81. DOI: 10.1056/NEJMra070553. View

Cerit L, Kemal H, Gulsen K, Ozcem B, Cerit Z, Duygu H . Relationship between Vitamin D and the development of atrial fibrillation after on-pump coronary artery bypass graft surgery. Cardiovasc J Afr. 2016; 28(2):104-107. PMC: 5488049. DOI: 10.5830/CVJA-2016-064. View

10.

Wong M, Delansorne R, Man R, Vanhoutte P . Vitamin D derivatives acutely reduce endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol. 2008; 295(1):H289-96. DOI: 10.1152/ajpheart.00116.2008. View

11.

Babu A, Meng X, Zou N, Yang X, Wang M, Song Y . Lipopolysaccharide stimulation of human aortic valve interstitial cells activates inflammation and osteogenesis. Ann Thorac Surg. 2008; 86(1):71-6. DOI: 10.1016/j.athoracsur.2008.03.008. View

12.

Gurses K, Kocyigit D, Yalcin M, Canpinar H, Oto M, Ozer N . Enhanced Platelet Toll-like Receptor 2 and 4 Expression in Acute Coronary Syndrome and Stable Angina Pectoris. Am J Cardiol. 2015; 116(11):1666-71. DOI: 10.1016/j.amjcard.2015.08.048. View

13.

Baiersdorfer M, Schwarz M, Seehafer K, Lehmann C, Heit A, Wagner H . Toll-like receptor 3 mediates expression of clusterin/apolipoprotein J in vascular smooth muscle cells stimulated with RNA released from necrotic cells. Exp Cell Res. 2010; 316(20):3489-500. DOI: 10.1016/j.yexcr.2010.07.022. View

14.

Camici M, Galetta F, Franzoni F, Carpi A, Zangeneh F . Vitamin D and heart. Intern Emerg Med. 2013; 8 Suppl 1:S5-9. DOI: 10.1007/s11739-013-0926-x. View

15.

Meng X, Ao L, Song Y, Babu A, Yang X, Wang M . Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis. Am J Physiol Cell Physiol. 2007; 294(1):C29-35. DOI: 10.1152/ajpcell.00137.2007. View

16.

Meehan M, Penckofer S . The Role of Vitamin D in the Aging Adult. J Aging Gerontol. 2015; 2(2):60-71. PMC: 4399494. DOI: 10.12974/2309-6128.2014.02.02.1. View

17.

Forrest K, Stuhldreher W . Prevalence and correlates of vitamin D deficiency in US adults. Nutr Res. 2011; 31(1):48-54. DOI: 10.1016/j.nutres.2010.12.001. View

18.

. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017; 390(10100):1151-1210. PMC: 5605883. DOI: 10.1016/S0140-6736(17)32152-9. View

19.

Spiro A, Buttriss J . Vitamin D: An overview of vitamin D status and intake in Europe. Nutr Bull. 2015; 39(4):322-350. PMC: 4288313. DOI: 10.1111/nbu.12108. View

20.

Sanchez-Lemus E, Murakami Y, Larrayoz-Roldan I, Moughamian A, Pavel J, Nishioku T . Angiotensin II AT1 receptor blockade decreases lipopolysaccharide-induced inflammation in the rat adrenal gland. Endocrinology. 2008; 149(10):5177-88. PMC: 2582913. DOI: 10.1210/en.2008-0242. View