Emerging Roles and Context of Circular RNAs

Overview

Journal Wiley Interdiscip Rev RNA

Publisher Wiley

Date 2016 Sep 10

PMID 27612318

Citations 89

Authors

Amaresh C Panda

Ioannis Grammatikakis

Rachel Munk

Myriam Gorospe

Kotb Abdelmohsen

Affiliations

Soon will be listed here.

Abstract

Circular RNAs (circRNAs) represent a large class of noncoding RNAs (ncRNAs) that have recently emerged as regulators of gene expression. They have been shown to suppress microRNAs, thereby increasing the translation and stability of the targets of such microRNAs. In this review, we discuss the emerging functions of circRNAs, including RNA transcription, splicing, turnover, and translation. We also discuss other possible facets of circRNAs that can influence their function depending on the cell context, such as circRNA abundance, subcellular localization, interacting partners (RNA, DNA, and proteins), dynamic changes in interactions following stimulation, and potential circRNA translation. The ensuing changes in gene expression patterns elicited by circRNAs are proposed to drive key cellular processes, such as cell proliferation, differentiation, and survival, that govern health and disease. WIREs RNA 2017, 8:e1386. doi: 10.1002/wrna.1386 For further resources related to this article, please visit the WIREs website.

Citing Articles

RNA-containing extracellular vesicles in infection.

Schemiko Almeida K, Rossi S, Alves L RNA Biol. 2024; 21(1):37-51.

PMID: 39589334 PMC: 11601058. DOI: 10.1080/15476286.2024.2431781.

Circular RNA expression in turkey skeletal muscle satellite cells is significantly altered by thermal challenge.

Powell A, Velleman S, Strasburg G, Abrahante Llorens J, Reed K Front Physiol. 2024; 15:1476487.

PMID: 39359572 PMC: 11445135. DOI: 10.3389/fphys.2024.1476487.

Unraveling the Regulatory Role of HuR/microRNA Axis in Colorectal Cancer Tumorigenesis.

Yadav V, Singh T, Sharma D, Garg V, Chakraborty P, Ghatak S Cancers (Basel). 2024; 16(18).

PMID: 39335155 PMC: 11430344. DOI: 10.3390/cancers16183183.

The Role of circHIPK3 in Tumorigenesis and Its Potential as a Biomarker in Lung Cancer.

Siedlecki E, Remiszewski P, Stec R Cells. 2024; 13(17.

PMID: 39273053 PMC: 11393915. DOI: 10.3390/cells13171483.

Small Extracellular Vesicle-Derived Circular RNA hsa_circ_0007386 as a Biomarker for the Diagnosis of Pleural Mesothelioma.

Zhand S, Liao J, Castorina A, Yuen M, Warkiani M, Cheng Y Cells. 2024; 13(12.

PMID: 38920665 PMC: 11201843. DOI: 10.3390/cells13121037.

References

Kramer M, Liang D, Tatomer D, Gold B, March Z, Cherry S . Combinatorial control of Drosophila circular RNA expression by intronic repeats, hnRNPs, and SR proteins. Genes Dev. 2015; 29(20):2168-82. PMC: 4617980. DOI: 10.1101/gad.270421.115. View

Jeck W, Sharpless N . Detecting and characterizing circular RNAs. Nat Biotechnol. 2014; 32(5):453-61. PMC: 4121655. DOI: 10.1038/nbt.2890. View

Nigro J, Cho K, Fearon E, Kern S, Ruppert J, Oliner J . Scrambled exons. Cell. 1991; 64(3):607-13. DOI: 10.1016/0092-8674(91)90244-s. View

Beckedorff F, Ayupe A, Crocci-Souza R, Amaral M, Nakaya H, Soltys D . The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation. PLoS Genet. 2013; 9(8):e1003705. PMC: 3749938. DOI: 10.1371/journal.pgen.1003705. View

Villegas V, Zaphiropoulos P . Neighboring gene regulation by antisense long non-coding RNAs. Int J Mol Sci. 2015; 16(2):3251-66. PMC: 4346893. DOI: 10.3390/ijms16023251. View

Enuka Y, Lauriola M, Feldman M, Sas-Chen A, Ulitsky I, Yarden Y . Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor. Nucleic Acids Res. 2015; 44(3):1370-83. PMC: 4756822. DOI: 10.1093/nar/gkv1367. View

Zheng Q, Bao C, Guo W, Li S, Chen J, Chen B . Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nat Commun. 2016; 7:11215. PMC: 4823868. DOI: 10.1038/ncomms11215. View

Rybak-Wolf A, Stottmeister C, Glazar P, Jens M, Pino N, Giusti S . Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Mol Cell. 2015; 58(5):870-85. DOI: 10.1016/j.molcel.2015.03.027. View

Schmitz K, Mayer C, Postepska A, Grummt I . Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes. Genes Dev. 2010; 24(20):2264-9. PMC: 2956204. DOI: 10.1101/gad.590910. View

10.

Meyer K, Patil D, Zhou J, Zinoviev A, Skabkin M, Elemento O . 5' UTR m(6)A Promotes Cap-Independent Translation. Cell. 2015; 163(4):999-1010. PMC: 4695625. DOI: 10.1016/j.cell.2015.10.012. View

11.

Zhang X, Wang H, Zhang Y, Lu X, Chen L, Yang L . Complementary sequence-mediated exon circularization. Cell. 2014; 159(1):134-147. DOI: 10.1016/j.cell.2014.09.001. View

12.

Wilusz J . Repetitive elements regulate circular RNA biogenesis. Mob Genet Elements. 2015; 5(3):1-7. PMC: 4588227. DOI: 10.1080/2159256X.2015.1045682. View

13.

Zhang Y, Xue W, Li X, Zhang J, Chen S, Zhang J . The Biogenesis of Nascent Circular RNAs. Cell Rep. 2016; 15(3):611-624. DOI: 10.1016/j.celrep.2016.03.058. View

14.

Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A . Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013; 495(7441):333-8. DOI: 10.1038/nature11928. View

15.

Barrett S, Wang P, Salzman J . Circular RNA biogenesis can proceed through an exon-containing lariat precursor. Elife. 2015; 4:e07540. PMC: 4479058. DOI: 10.7554/eLife.07540. View

16.

Ivanov A, Memczak S, Wyler E, Torti F, Porath H, Orejuela M . Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals. Cell Rep. 2015; 10(2):170-7. DOI: 10.1016/j.celrep.2014.12.019. View

17.

Liang D, Wilusz J . Short intronic repeat sequences facilitate circular RNA production. Genes Dev. 2014; 28(20):2233-47. PMC: 4201285. DOI: 10.1101/gad.251926.114. View

18.

Lukiw W . Circular RNA (circRNA) in Alzheimer's disease (AD). Front Genet. 2014; 4:307. PMC: 3875874. DOI: 10.3389/fgene.2013.00307. View

19.

Orang A, Safaralizadeh R, Kazemzadeh-Bavili M . Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation. Int J Genomics. 2014; 2014:970607. PMC: 4142390. DOI: 10.1155/2014/970607. View

20.

Li Z, Huang C, Bao C, Chen L, Lin M, Wang X . Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 2015; 22(3):256-64. DOI: 10.1038/nsmb.2959. View