Exosomal Circular RNA: a Signature for Lung Cancer Progression

Overview

Journal Cancer Cell Int

Publisher Biomed Central

Date 2022 Dec 2

PMID 36457039

Authors

Bashdar Mahmud Hussen

Snur Rasool Abdullah

Goran Sedeeq Hama Faraj

Mohammed Fatih Rasul

Abbas Salihi

Soudeh Ghafouri-Fard

Mohammad Taheri

Majid Mokhtari

Affiliations

Soon will be listed here.

Abstract

Membrane vesicles having a diameter of 30-150 nm are known as exosomes. Several cancer types secrete exosomes, which may contain proteins, circular RNAs (circRNAs), microRNAs, or DNA. CircRNAs are endogenous RNAs that do not code for proteins and can create continuous and covalently closed loops. In cancer pathogenesis, especially metastasis, exosomal circRNAs (exo-circRNAs) have a crucial role mainly due to the frequently aberrant expression levels within tumors. However, neither the activities nor the regulatory mechanisms of exo-circRNAs in advancing lung cancer (LC) are obvious. A better understanding of the regulation and network connections of exo-circRNAs will lead to better treatment for LCs. The main objective of the current review is to highlight the functions and mechanisms of exo-circRNAs in LC and assess the relationships between exo-circRNA dysregulation and LC progression. In addition, underline the possible therapeutic targets based on exo-circRNA modulating.

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