Serum Levels of Interleukin-17 and Adiponectin Are Associated with Infrapatellar Fat Pad Volume and Signal Intensity Alteration in Patients with Knee Osteoarthritis

Overview

Journal Arthritis Res Ther

Publisher Biomed Central

Specialty Rheumatology

Date 2016 Aug 28

PMID 27566142

Citations 19

Authors

Kang Wang

Jianhua Xu

Jingyu Cai

Shuang Zheng

Weiyu Han

Benny Antony

Changhai Ding

Affiliations

Soon will be listed here.

Abstract

Background: In the present study, we sought to generate hypotheses regarding the associations of serum levels of interleukin (IL)-17, adiponectin, and resistin with magnetic resonance imaging-measured infrapatellar fat pad (IPFP) size and signal intensity alterations in patients with knee osteoarthritis (OA).

Methods: A total of 170 subjects with symptomatic knee OA (mean age 55.4 years, range 34-74, 88.2 % females) were included. IPFP volume was measured on T1-weighted spoiled gradient-recalled acquisition in the steady state images and was computed by using a software program. IPFP high signal intensity (grades 0-3) was assessed on T2-weighted fast spin echo images. Serum IL-17, adiponectin, and resistin levels were measured using an enzyme-linked immunosorbent assay.

Results: In multivariable analyses, serum IL-17 was negatively associated with IPFP volume (β = -0.185, 95 % CI -0.337 to -0.034) but positively associated with the severity of IPFP signal intensity alteration (OR 1.23, 95 % CI 1.06-1.42) after adjustment for age, sex, weight, and height. Serum adiponectin was positively associated with IPFP volume (β = 0.016, 95 % CI 0.001-0.032) but negatively associated with IPFP signal intensity alteration (OR 0.99, 95 % CI 0.98-1.00) after adjustment for covariates. Resistin was positively associated with IPFP signal intensity alteration (OR 1.13, 95 % CI 1.04-1.23) but not with IPFP volume. The significant associations of adiponectin or resistin disappeared after further adjustment for IL-17; in contrast, the significant associations of IL-17 remained after further adjustment for adiponectin.

Conclusions: While serum IL-17 and resistin were associated with reduced IPFP volume and/or increased abnormal signal intensity alteration, serum adiponectin had opposite associations that were largely through IL-17. These findings suggest that serum adipocytokines may have a role to play in IPFP changes of knee OA.

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References

Grotle M, Hagen K, Natvig B, Dahl F, Kvien T . Obesity and osteoarthritis in knee, hip and/or hand: an epidemiological study in the general population with 10 years follow-up. BMC Musculoskelet Disord. 2008; 9:132. PMC: 2573886. DOI: 10.1186/1471-2474-9-132. View

Zheng S, Xu J, Xu S, Zhang M, Huang S, He F . Association between circulating adipokines, radiographic changes, and knee cartilage volume in patients with knee osteoarthritis. Scand J Rheumatol. 2015; 45(3):224-9. DOI: 10.3109/03009742.2015.1083053. View

Kellgren J, Lawrence J . Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957; 16(4):494-502. PMC: 1006995. DOI: 10.1136/ard.16.4.494. View

Gandhi R, Takahashi M, Virtanen C, Syed K, Davey J, Mahomed N . Microarray analysis of the infrapatellar fat pad in knee osteoarthritis: relationship with joint inflammation. J Rheumatol. 2011; 38(9):1966-72. DOI: 10.3899/jrheum.101302. View

Honorati M, Meliconi R, Pulsatelli L, Cane S, Frizziero L, Facchini A . High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chondrocytes from arthritis patients. Rheumatology (Oxford). 2001; 40(5):522-7. DOI: 10.1093/rheumatology/40.5.522. View

Han W, Aitken D, Zhu Z, Halliday A, Wang X, Antony B . Signal intensity alteration in the infrapatellar fat pad at baseline for the prediction of knee symptoms and structure in older adults: a cohort study. Ann Rheum Dis. 2015; 75(10):1783-8. DOI: 10.1136/annrheumdis-2015-208360. View

Hui W, Litherland G, Elias M, Kitson G, Cawston T, Rowan A . Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases. Ann Rheum Dis. 2011; 71(3):455-62. DOI: 10.1136/annrheumdis-2011-200372. View

Lago R, Gomez R, Otero M, Lago F, Gallego R, Dieguez C . A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes. Osteoarthritis Cartilage. 2008; 16(9):1101-9. DOI: 10.1016/j.joca.2007.12.008. View

Roemer F, Kwoh C, Hannon M, Hunter D, Eckstein F, Fujii T . What comes first? Multitissue involvement leading to radiographic osteoarthritis: magnetic resonance imaging-based trajectory analysis over four years in the osteoarthritis initiative. Arthritis Rheumatol. 2015; 67(8):2085-96. PMC: 4519416. DOI: 10.1002/art.39176. View

10.

Han W, Cai S, Liu Z, Jin X, Wang X, Antony B . Infrapatellar fat pad in the knee: is local fat good or bad for knee osteoarthritis?. Arthritis Res Ther. 2014; 16(4):R145. PMC: 4227074. DOI: 10.1186/ar4607. View

11.

Fernandez-Madrid F, Karvonen R, Teitge R, Miller P, An T, Negendank W . Synovial thickening detected by MR imaging in osteoarthritis of the knee confirmed by biopsy as synovitis. Magn Reson Imaging. 1995; 13(2):177-83. DOI: 10.1016/0730-725x(94)00119-n. View

12.

Distel E, Cadoudal T, Durant S, Poignard A, Chevalier X, Benelli C . The infrapatellar fat pad in knee osteoarthritis: an important source of interleukin-6 and its soluble receptor. Arthritis Rheum. 2009; 60(11):3374-7. DOI: 10.1002/art.24881. View

13.

Roemer F, Guermazi A, Zhang Y, Yang M, Hunter D, Crema M . Hoffa's Fat Pad: Evaluation on Unenhanced MR Images as a Measure of Patellofemoral Synovitis in Osteoarthritis. AJR Am J Roentgenol. 2009; 192(6):1696-700. DOI: 10.2214/AJR.08.2038. View

14.

de Boer T, van Spil W, Huisman A, Polak A, Bijlsma J, Lafeber F . Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage. Osteoarthritis Cartilage. 2012; 20(8):846-53. DOI: 10.1016/j.joca.2012.05.002. View

15.

Klein-Wieringa I, Kloppenburg M, Bastiaansen-Jenniskens Y, Yusuf E, Kwekkeboom J, El-Bannoudi H . The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype. Ann Rheum Dis. 2011; 70(5):851-7. DOI: 10.1136/ard.2010.140046. View

16.

Yusuf E, Ioan-Facsinay A, Bijsterbosch J, Klein-Wieringa I, Kwekkeboom J, Slagboom P . Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis. Ann Rheum Dis. 2011; 70(7):1282-4. DOI: 10.1136/ard.2010.146282. View

17.

Clockaerts S, Bastiaansen-Jenniskens Y, Feijt C, De Clerck L, Verhaar J, Zuurmond A . Cytokine production by infrapatellar fat pad can be stimulated by interleukin 1β and inhibited by peroxisome proliferator activated receptor α agonist. Ann Rheum Dis. 2012; 71(6):1012-8. DOI: 10.1136/annrheumdis-2011-200688. View

18.

Klein-Wieringa I, Andersen S, Herb-van Toorn L, Kwekkeboom J, van der Helm-van Mil A, Meulenbelt I . Are baseline high molecular weight adiponectin levels associated with radiographic progression in rheumatoid arthritis and osteoarthritis?. J Rheumatol. 2014; 41(5):853-7. DOI: 10.3899/jrheum.130888. View

19.

Choe J, Bae J, Jung H, Park S, Lee H, Kim S . Serum resistin level is associated with radiographic changes in hand osteoarthritis: cross-sectional study. Joint Bone Spine. 2011; 79(2):160-5. DOI: 10.1016/j.jbspin.2011.04.009. View

20.

Saddik D, McNally E, Richardson M . MRI of Hoffa's fat pad. Skeletal Radiol. 2004; 33(8):433-44. DOI: 10.1007/s00256-003-0724-z. View