Plasma MiR-136 Can Be Used to Screen Patients with Knee Osteoarthritis from Healthy Controls by Targeting IL-17

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2018 Sep 21

PMID 30233690

Citations 9

Authors

Lei Wan

Qiang Zhao

Gang Niu

Tai Xiang

Cuilei Ding

Shijie Wang

Affiliations

Soon will be listed here.

Abstract

The current study mainly evaluated the plasma level of microRNA (miR)-136 in knee osteoarthritis (KOA) patients and determined if miR-136 could be used as a potential biomarker to screen KOA patients from healthy controls. It was demonstrated that plasma miR-136 was significantly decreased in the plasma of KOA patients. Moreover, the reduction in plasma miR-136 negatively correlated with the severity of KOA. Additionally, the increase in the serum interleukin (IL)-17 level positively correlated with the severity of KOA. More importantly, dual luciferase assays and western blot assays indicated that IL-17 was a target gene of miR-136. Further analysis showed that plasma miR-136 could be used as a biomarker to screen KOA patients from healthy controls. In summary, for the first time, the present study revealed that through targeting IL-17, decreased plasma miR-136 levels could be used as a potential biomarker to screen KOA patients from healthy controls.

Citing Articles

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