The Potential Impact of Bone Tissue Engineering in the Clinic

Overview

Journal Regen Med

Specialty Biotechnology

Date 2016 Aug 24

PMID 27549369

Citations 27

Authors

Ruchi Mishra

Tyler Bishop

Ian L Valerio

John P Fisher

David Dean

Affiliations

Soon will be listed here.

Abstract

Bone tissue engineering (BTE) intends to restore structural support for movement and mineral homeostasis, and assist in hematopoiesis and the protective functions of bone in traumatic, degenerative, cancer, or congenital malformation. While much effort has been put into BTE, very little of this research has been translated to the clinic. In this review, we discuss current regenerative medicine and restorative strategies that utilize tissue engineering approaches to address bone defects within a clinical setting. These approaches involve the primary components of tissue engineering: cells, growth factors and biomaterials discussed briefly in light of their clinical relevance. This review also presents upcoming advanced approaches for BTE applications and suggests a probable workpath for translation from the laboratory to the clinic.

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References

Thomson R, Mikos A, Beahm E, Lemon J, Satterfield W, Aufdemorte T . Guided tissue fabrication from periosteum using preformed biodegradable polymer scaffolds. Biomaterials. 1999; 20(21):2007-18. DOI: 10.1016/s0142-9612(99)00103-9. View

Laursen M, Hoy K, Hansen E, Gelineck J, Christensen F, Bunger C . Recombinant bone morphogenetic protein-7 as an intracorporal bone growth stimulator in unstable thoracolumbar burst fractures in humans: preliminary results. Eur Spine J. 2000; 8(6):485-90. PMC: 3611219. DOI: 10.1007/s005860050210. View

Burg K, Porter S, Kellam J . Biomaterial developments for bone tissue engineering. Biomaterials. 2000; 21(23):2347-59. DOI: 10.1016/s0142-9612(00)00102-2. View

Kenneth Burkus J, Transfeldt E, Kitchel S, Watkins R, Balderston R . Clinical and radiographic outcomes of anterior lumbar interbody fusion using recombinant human bone morphogenetic protein-2. Spine (Phila Pa 1976). 2002; 27(21):2396-408. DOI: 10.1097/00007632-200211010-00015. View

Krampera M, Glennie S, Dyson J, Scott D, Laylor R, Simpson E . Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood. 2002; 101(9):3722-9. DOI: 10.1182/blood-2002-07-2104. View

Kenneth Burkus J, Heim S, Gornet M, Zdeblick T . Is INFUSE bone graft superior to autograft bone? An integrated analysis of clinical trials using the LT-CAGE lumbar tapered fusion device. J Spinal Disord Tech. 2003; 16(2):113-22. DOI: 10.1097/00024720-200304000-00001. View

Le Blanc K, Tammik C, Rosendahl K, Zetterberg E, Ringden O . HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol. 2003; 31(10):890-6. DOI: 10.1016/s0301-472x(03)00110-3. View

Dean D, Min K, Bond A . Computer aided design of large-format prefabricated cranial plates. J Craniofac Surg. 2003; 14(6):819-32. DOI: 10.1097/00001665-200311000-00002. View

De Biase P, Capanna R . Clinical applications of BMPs. Injury. 2005; 36 Suppl 3:S43-6. DOI: 10.1016/j.injury.2005.07.034. View

10.

Franz-Odendaal T, Hall B, Witten P . Buried alive: how osteoblasts become osteocytes. Dev Dyn. 2005; 235(1):176-90. DOI: 10.1002/dvdy.20603. View

11.

Parson A . The long journey from stem cells to medical product. Cell. 2006; 125(1):9-11. DOI: 10.1016/j.cell.2006.03.024. View

12.

McKay W, Peckham S, Badura J . A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE Bone Graft). Int Orthop. 2007; 31(6):729-34. PMC: 2266665. DOI: 10.1007/s00264-007-0418-6. View

13.

Stevens B, Yang Y, Mohandas A, Stucker B, Nguyen K . A review of materials, fabrication methods, and strategies used to enhance bone regeneration in engineered bone tissues. J Biomed Mater Res B Appl Biomater. 2007; 85(2):573-82. DOI: 10.1002/jbm.b.30962. View

14.

Benglis D, Wang M, Levi A . A comprehensive review of the safety profile of bone morphogenetic protein in spine surgery. Neurosurgery. 2008; 62(5 Suppl 2):ONS423-31. DOI: 10.1227/01.neu.0000326030.24220.d8. View

15.

Ekrol I, Hajducka C, Court-Brown C, McQueen M . A comparison of RhBMP-7 (OP-1) and autogenous graft for metaphyseal defects after osteotomy of the distal radius. Injury. 2008; 39 Suppl 2:S73-82. DOI: 10.1016/S0020-1383(08)70018-4. View

16.

Kanakaris N, Calori G, Verdonk R, Burssens P, De Biase P, Capanna R . Application of BMP-7 to tibial non-unions: a 3-year multicenter experience. Injury. 2008; 39 Suppl 2:S83-90. DOI: 10.1016/S0020-1383(08)70019-6. View

17.

Caplan A . Why are MSCs therapeutic? New data: new insight. J Pathol. 2008; 217(2):318-24. PMC: 8793150. DOI: 10.1002/path.2469. View

18.

Grayson W, Frohlich M, Yeager K, Bhumiratana S, Chan M, Cannizzaro C . Engineering anatomically shaped human bone grafts. Proc Natl Acad Sci U S A. 2009; 107(8):3299-304. PMC: 2840502. DOI: 10.1073/pnas.0905439106. View

19.

Niemeyer P, Fechner K, Milz S, Richter W, Suedkamp N, Mehlhorn A . Comparison of mesenchymal stem cells from bone marrow and adipose tissue for bone regeneration in a critical size defect of the sheep tibia and the influence of platelet-rich plasma. Biomaterials. 2010; 31(13):3572-9. DOI: 10.1016/j.biomaterials.2010.01.085. View

20.

Probst F, Hutmacher D, Muller D, Machens H, Schantz J . [Calvarial reconstruction by customized bioactive implant]. Handchir Mikrochir Plast Chir. 2010; 42(6):369-73. DOI: 10.1055/s-0030-1248310. View