Cortical Feedback Regulates Feedforward Retinogeniculate Refinement

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2016 Aug 23

PMID 27545712

Citations 33

Authors

Andrew D Thompson

Nathalie Picard

Lia Min

Michela Fagiolini

Chinfei Chen

Affiliations

Soon will be listed here.

Abstract

According to the prevailing view of neural development, sensory pathways develop sequentially in a feedforward manner, whereby each local microcircuit refines and stabilizes before directing the wiring of its downstream target. In the visual system, retinal circuits are thought to mature first and direct refinement in the thalamus, after which cortical circuits refine with experience-dependent plasticity. In contrast, we now show that feedback from cortex to thalamus critically regulates refinement of the retinogeniculate projection during a discrete window in development, beginning at postnatal day 20 in mice. Disrupting cortical activity during this window, pharmacologically or chemogenetically, increases the number of retinal ganglion cells innervating each thalamic relay neuron. These results suggest that primary sensory structures develop through the concurrent and interdependent remodeling of subcortical and cortical circuits in response to sensory experience, rather than through a simple feedforward process. Our findings also highlight an unexpected function for the corticothalamic projection.

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