EphA5 and EphA6: Regulation of Neuronal and Spine Morphology

Overview

Journal Cell Biosci

Publisher Biomed Central

Specialty Biology

Date 2016 Aug 5

PMID 27489614

Citations 21

Authors

Gitanjali Das

Qili Yu

Ryan Hui

Kenneth Reuhl

Nicholas W Gale

Renping Zhou

Affiliations

Soon will be listed here.

Abstract

Background: The Eph family of receptor tyrosine kinases plays important roles in neural development. Previous studies have implicated Eph receptors and their ligands, the ephrins, in neuronal migration, axon bundling and guidance to specific targets, dendritic spine formation and neural plasticity. However, specific contributions of EphA5 and EphA6 receptors to the regulation of neuronal cell morphology have not been well studied.

Results: Here we show that deletion of EphA5 and EphA6 results in abnormal Golgi staining patterns of cells in the brain, and abnormal spine morphology.

Conclusion: These observations suggest novel functions of these Eph receptors in the regulation of neuronal and spine structure in brain development and function.

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