MiR-132 Loss De-represses ITPKB and Aggravates Amyloid and TAU Pathology in Alzheimer's Brain

Overview

Journal EMBO Mol Med

Specialty Molecular Biology

Date 2016 Aug 4

PMID 27485122

Citations 88

Authors

Evgenia Salta

Annerieke Sierksma

Elke Vanden Eynden

Bart De Strooper

Affiliations

Soon will be listed here.

Abstract

microRNA-132 (miR-132) is involved in prosurvival, anti-inflammatory and memory-promoting functions in the nervous system and has been found consistently downregulated in Alzheimer's disease (AD). Whether and how miR-132 deficiency impacts AD pathology remains, however, unaddressed. We show here that miR-132 loss exacerbates both amyloid and TAU pathology via inositol 1,4,5-trisphosphate 3-kinase B (ITPKB) upregulation in an AD mouse model. This leads to increased ERK1/2 and BACE1 activity and elevated TAU phosphorylation. We confirm downregulation of miR-132 and upregulation of ITPKB in three distinct human AD patient cohorts, indicating the pathological relevance of this pathway in AD.

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