Mycotoxin Patulin Suppresses Innate Immune Responses by Mitochondrial Dysfunction and P62/Sequestosome-1-dependent Mitophagy

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2016 Jul 27

PMID 27458013

Citations 22

Authors

Wan-Ting Tsai

Yin-Chiu Lo

Ming-Sian Wu

Chia-Yang Li

Yi-Ping Kuo

Yi-Hui Lai

Yu Tsai

Kai-Chieh Chen

Tsung-Hsien Chuang

Chun-Hsu Yao

Jinq-Chyi Lee

Li-Chung Hsu

John T-A Hsu

Guann-Yi Yu

Affiliations

Soon will be listed here.

Abstract

Innate immune responses are important for pathogen elimination and adaptive immune response activation. However, excess inflammation may contribute to immunopathology and disease progression (e.g. inflammation-associated hepatocellular carcinoma). Immune modulation resulting from pattern recognition receptor-induced responses is a potential strategy for controlling immunopathology and related diseases. This study demonstrates that the mycotoxin patulin suppresses Toll-like receptor- and RIG-I/MAVS-dependent cytokine production through GSH depletion, mitochondrial dysfunction, the activation of p62-associated mitophagy, and p62-TRAF6 interaction. Blockade of autophagy restored the immunosuppressive activity of patulin, and pharmacological activation of p62-dependent mitophagy directly reduced RIG-I-like receptor-dependent inflammatory cytokine production. These results demonstrated that p62-dependent mitophagy has an immunosuppressive role to innate immune response and might serve as a potential immunomodulatory target for inflammation-associated diseases.

Citing Articles

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Immunosuppressive effects of the mycotoxin patulin in macrophages.

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Patulin Ameliorates Hypertrophied Lipid Accumulation and Lipopolysaccharide-Induced Inflammatory Response by Modulating Mitochondrial Respiration.

Hong S, Park S, Lee J, Park S, Kim Y, Park J Antioxidants (Basel). 2023; 12(9).

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Patulin Alters Insulin Signaling and Metabolic Flexibility in HepG2 and HEK293 Cells.

Pillay Y, Nagiah S, Chuturgoon A Toxins (Basel). 2023; 15(4).

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